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    AI2 intron-encoded reverse transcriptase aI2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AI2
    Official Full Name
    intron-encoded reverse transcriptase aI2
    Primary source
    SGD:S000007262
    Locus tag
    Q0055
    See related
    AllianceGenome:SGD:S000007262; FungiDB:Q0055; VEuPathDB:Q0055
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA-directed DNA polymerase activity. Involved in intron homing. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AI2 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (13818..18830)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene intron-encoded DNA endonuclease aI5 alpha Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI1 Neighboring gene intron-encoded DNA endonuclease aI3 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing. Huang HR, et al. Mol Cell Biol, 2003 Dec. PMID 14612420, Free PMC Article
    2. Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA. Zimmerly S, et al. J Mol Biol, 1999 Jun 11. PMID 10356323
    3. Group II intron mobility occurs by target DNA-primed reverse transcription. Zimmerly S, et al. Cell, 1995 Aug 25. PMID 7664334
    4. Efficient integration of an intron RNA into double-stranded DNA by reverse splicing. Yang J, et al. Nature, 1996 May 23. PMID 8692273
    5. Splicing-defective mutants of the yeast mitochondrial COXI gene can be corrected by transformation with a hybrid maturase gene. Anziano PQ, et al. Proc Natl Acad Sci U S A, 1991 Jul 1. PMID 1648225, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homing of group II introns IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intron homing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intron-encoded reverse transcriptase aI2
    NP_009309.1
    • Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      13818..18830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009309.1 intron-encoded reverse transcriptase aI2 (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009309.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7NYJ2, P03876, Q9ZZX4
      UniProtKB/TrEMBL
      A0A0H3WHZ6
      Conserved Domains (3) summary
      cd01651
      Location:344 → 613
      RT_G2_intron; Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable element with ...
      pfam01348
      Location:638 → 781
      Intron_maturas2; Type II intron maturase
      cl00275
      Location:3 → 68
      Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03876.2

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