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    APM2 Apm2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856367, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APM2
    Official Full Name
    Apm2p
    Primary source
    SGD:S000001011
    Locus tag
    YHL019C
    See related
    AllianceGenome:SGD:S000001011; FungiDB:YHL019C; VEuPathDB:YHL019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable clathrin adaptor activity. Involved in Golgi to vacuole transport. Located in early endosome and trans-Golgi network. Orthologous to human STON1-GTF2A1L (STON1-GTF2A1L readthrough); STON1 (stonin 1); and STON2 (stonin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APM2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (67731..69548, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Aim17p Neighboring gene transcriptional regulator OPI1 Neighboring gene 4a-hydroxytetrahydrobiopterin dehydratase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Stepp JD, et al. Mol Biol Cell, 1995 Jan. PMID 7749194, Free PMC Article
    2. Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae. Phelan JP, et al. J Cell Sci, 2006 Oct 15. PMID 17003107
    3. A simple and inexpensive quantitative technique for determining chemical sensitivity in Saccharomyces cerevisiae. Hung CW, et al. Sci Rep, 2018 Aug 9. PMID 30093662, Free PMC Article
    4. TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays. Kim C, et al. BMC Bioinformatics, 2007 Apr 18. PMID 17442117, Free PMC Article
    5. The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting. Whitfield ST, et al. Mol Biol Cell, 2016 Feb 1. PMID 26658609, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mil1 is a predicted lipase that binds Apm2 but not Apm1 and contributes to its membrane recruitment.
      Title: The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Apm2p
    NP_011844.1
    • hypothetical protein; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      67731..69548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179099.1 → NP_011844.1  TPA: Apm2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKR4, P38700
      UniProtKB/TrEMBL
      C7GIR7, G2WF47, N1P4X3
      Conserved Domains (2) summary
      cd09250
      Location:256 → 603
      AP-1_Mu1_Cterm; C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1
      cd14828
      Location:3 → 138
      AP_Mu_N; AP complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38700.1

    Gene LinkOut

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