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    ROM1 Rho family guanine nucleotide exchange factor ROM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ROM1
    Official Full Name
    Rho family guanine nucleotide exchange factor ROM1
    Primary source
    SGD:S000003302
    Locus tag
    YGR070W
    See related
    AllianceGenome:SGD:S000003302; FungiDB:YGR070W; VEuPathDB:YGR070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SKC1
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in small GTPase-mediated signal transduction. Located in cytoplasm. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ROM1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (627806..631273)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Art5p Neighboring gene Env11p Neighboring gene Upf3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The localization of nuclear exporters of the importin-beta family is regulated by Snf1 kinase, nutrient supply and stress. Quan X, et al. Biochim Biophys Acta, 2007 Jul. PMID 17544521
    2. Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. Ozaki K, et al. EMBO J, 1996 May 1. PMID 8641285, Free PMC Article
    3. Down-regulation of Pkc1-mediated signaling by the deubiquitinating enzyme Ubp3. Wang Y, et al. J Biol Chem, 2008 Jan 25. PMID 17986446
    4. A MAP kinase dependent feedback mechanism controls Rho1 GTPase and actin distribution in yeast. Guo S, et al. PLoS One, 2009 Jun 30. PMID 19564916, Free PMC Article
    5. Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae. Marcoux N, et al. Genetics, 2000 Oct. PMID 11014808, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell wall organization or biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho family guanine nucleotide exchange factor ROM1
    NP_011584.2
    • Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      627806..631273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181199.2 → NP_011584.2  TPA: Rho family guanine nucleotide exchange factor ROM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011584.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53046, Q92326
      UniProtKB/TrEMBL
      B3LIF5, N1P3J2
      Conserved Domains (1) summary
      COG5422
      Location:1 → 1155
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53046.2

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