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    CKB1 casein kinase 2 regulatory subunit CKB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CKB1
    Official Full Name
    casein kinase 2 regulatory subunit CKB1
    Primary source
    SGD:S000002987
    Locus tag
    YGL019W
    See related
    AllianceGenome:SGD:S000002987; FungiDB:YGL019W; VEuPathDB:YGL019W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase inhibitor activity. Involved in DNA damage response; regulation of transcription by RNA polymerase I; and regulation of transcription by RNA polymerase III. Part of UTP-C complex and protein kinase CK2 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CKB1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (458156..458992)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene protein kinase ALK1 Neighboring gene GET complex subunit GET1 Neighboring gene J-type chaperone JAC1 Neighboring gene arginyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and disruption of CKB1, the gene encoding the 38-kDa beta subunit of Saccharomyces cerevisiae casein kinase II (CKII). Deletion of CKII regulatory subunits elicits a salt-sensitive phenotype. Bidwai AP, et al. J Biol Chem, 1995 May 5. PMID 7737972
    2. Nutritional modulation of CK2 in Saccharomyces cerevisiae: regulating the activity of a constitutive enzyme. Tripodi F, et al. Mol Cell Biochem, 2011 Oct. PMID 21750980
    3. Casein kinase II of yeast contains two distinct alpha polypeptides and an unusually large beta subunit. Padmanabha R, et al. J Biol Chem, 1987 Feb 5. PMID 3468112
    4. Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. Bergkessel M, et al. RNA, 2011 Aug. PMID 21697354, Free PMC Article
    5. Transcriptional regulation of the S. cerevisiae ENA1 gene by casein kinase II. Tenney KA, et al. Mol Cell Biochem, 1999 Jan. PMID 10094405

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ckb1 is differentially phosphorylated in vivo and that Kns1 mediates this phosphorylation when nutrients are limiting and under all tested stress conditions.
      Title: Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.
    2. These data may help to elucidate the role of yeast protein kinase CK2beta/beta' subunits in the regulation of holoenzyme assembly and phosphotransferase activity.
      Title: Yeast holoenzyme of protein kinase CK2 requires both beta and beta' regulatory subunits for its activity.
    3. Yeast transcription elongation factor Elf1 has been identified as a new substrate for protein kinase CK2 and coimmunoprecipitation shows that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of CK2.
      Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UTP-C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UTP-C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein kinase CK2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase 2 regulatory subunit CKB1
    NP_011496.3
    • Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      458156..458992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180884.3 → NP_011496.3  TPA: casein kinase 2 regulatory subunit CKB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011496.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUB8, P43639, Q9URG5
      UniProtKB/TrEMBL
      A6ZUX4, B3LIN4, C7GSA5, C8Z8M3, G2WE74, N1P1Z9
      Conserved Domains (1) summary
      COG5041
      Location:1 → 278
      SKB2; Casein kinase II, beta subunit [Signal transduction mechanisms / Cell division and chromosome partitioning / Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43639.1

    Gene LinkOut

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