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    MON1 Mon1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MON1
    Official Full Name
    Mon1p
    Primary source
    SGD:S000003092
    Locus tag
    YGL124C
    See related
    AllianceGenome:SGD:S000003092; FungiDB:YGL124C; VEuPathDB:YGL124C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AUT12
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-5-phosphate binding activity; and phosphatidylserine binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in macroautophagy; protein targeting to vacuole; and vesicle docking. Located in cytosol; endosome; and fungal-type vacuole membrane. Part of Mon1-Ccz1 complex. Orthologous to several human genes including MON1B (MON1 homolog B, secretory trafficking associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MON1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (274780..276714, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Scs3p Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET13 Neighboring gene ribosomal 40S subunit protein S2 Neighboring gene mRNA-binding protein NAB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterisation of the SAND protein family: a study based on comparative genomics, structural bioinformatics and phylogeny. Cottage A, et al. Cell Mol Biol Lett, 2004. PMID 15647795
    2. Yeast Mon1p/Aut12p functions in vacuolar fusion of autophagosomes and cvt-vesicles. Meiling-Wesse K, et al. FEBS Lett, 2002 Oct 23. PMID 12387888
    3. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. Wang CW, et al. J Biol Chem, 2002 Dec 6. PMID 12364329, Free PMC Article
    4. Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1. Kiontke S, et al. Nat Commun, 2017 Jan 4. PMID 28051187, Free PMC Article
    5. The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes. Cabrera M, et al. J Cell Sci, 2014 Mar 1. PMID 24413168, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors find that Mon1-Ccz1 directly binds to Atg8, the yeast homolog of the members of the mammalian LC3 protein family.
      Title: Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure.
    2. Mon1 is recruited to endosomes and vacuoles by PI3P and, likely after activating Ypt7, is phosphorylated and released from vacuoles for recycling.
      Title: Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3.
    3. Guanine nucleotide exchange factor activity of the Mon1-Ccz1 complex towards Ypt7 requires the interface formed by their longin domains.
      Title: The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.
    4. Data indicate that the Mon1-Ccz1 complex triggers endosomal maturation by activating Ypt7 on late endosomes.
      Title: The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.
    5. These results suggest that the Ccz1p-Mon1p-Ypt7p complex is involved in fusion of transport vesicles to multiple target membranes in yeast cells.
      Title: The Saccharomyces cerevisiae protein Ccz1p interacts with components of the endosomal fusion machinery.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuolar membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuolar membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Mon1-Ccz1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in multivesicular body membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mon1p
    NP_011391.2
    • Subunit of heterodimeric guanine nucleotide exchange factor (GEF); subunit of Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to vacuolar membrane; required for autophagy, CVT pathway, and mitophagy; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      274780..276714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180989.2 → NP_011391.2  TPA: Mon1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011391.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU24, P53129
      UniProtKB/TrEMBL
      C7GM15, N1P318
      Conserved Domains (1) summary
      pfam03164
      Location:181 → 643
      Mon1; Trafficking protein Mon1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53129.2

    Gene LinkOut

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