PCM1 phosphoacetylglucosamine mutase PCM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PCM1
Official Full Name: phosphoacetylglucosamine mutase PCM1
Primary source: SGD:S000000784
Locus tag: YEL058W
See related: AllianceGenome:SGD:S000000784; FungiDB:YEL058W; VEuPathDB:YEL058W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AGM1
Summary: Enables phosphoacetylglucosamine mutase activity. Involved in chitin biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PCM1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (43252..44925)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoacetylglucosamine mutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoacetylglucosamine mutase activity	IEA Inferred from Electronic Annotation more info
enables phosphoacetylglucosamine mutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in chitin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoacetylglucosamine mutase PCM1

NP_010856.1

EC 5.4.2.3

Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

43252..44925

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178873.1 → NP_010856.1 TPA: phosphoacetylglucosamine mutase PCM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010856.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLJ2, P38628

UniProtKB/TrEMBL

A6ZQP3, G2WCH6, N1P720

Conserved Domains (1) summary

cd03086
Location:24 → 553

PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...