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    NCB2 negative cofactor 2 transcription regulator complex subunit NCB2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NCB2
    Official Full Name
    negative cofactor 2 transcription regulator complex subunit NCB2
    Primary source
    SGD:S000002805
    Locus tag
    YDR397C
    See related
    AllianceGenome:SGD:S000002805; FungiDB:YDR397C; VEuPathDB:YDR397C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YDR1
    Summary
    Enables chromatin binding activity; core promoter sequence-specific DNA binding activity; and transcription corepressor activity. Contributes to TBP-class protein binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to heat; and regulation of DNA-templated transcription. Located in nucleus. Part of negative cofactor 2 complex. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NCB2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (1266366..1266898, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT3 Neighboring gene Sxm1p Neighboring gene Utp5p Neighboring gene hypoxanthine phosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Kim S, et al. Proc Natl Acad Sci U S A, 1997 Feb 4. PMID 9023340, Free PMC Article
    2. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Gadbois EL, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096360, Free PMC Article
    3. The dual control of TFIIB recruitment by NC2 is gene specific. Masson P, et al. Nucleic Acids Res, 2008 Feb. PMID 18048413, Free PMC Article
    4. Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Cang Y, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12237409, Free PMC Article
    5. Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Geisberg JV, et al. Mol Cell Biol, 2001 Apr. PMID 11283253, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA polymerase II transcription preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of negative cofactor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of negative cofactor 2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of negative cofactor 2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of negative cofactor 2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    negative cofactor 2 transcription regulator complex subunit NCB2
    NP_010685.1
    • Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1266366..1266898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180705.1 → NP_010685.1  TPA: negative cofactor 2 transcription regulator complex subunit NCB2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT30, O00064, P87340, Q04176, Q92317
      UniProtKB/TrEMBL
      A6ZYZ7, B3LFQ4, C7GSC6, C8Z5W1, G2WBD6, N1P8T8
      Conserved Domains (1) summary
      COG5150
      Location:1 → 146
      COG5150; Class 2 transcription repressor NC2, beta subunit (Dr1) [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92317.1

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