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    APM3 Apm3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APM3
    Official Full Name
    Apm3p
    Primary source
    SGD:S000000492
    Locus tag
    YBR288C
    See related
    AllianceGenome:SGD:S000000492; FungiDB:YBR288C; VEuPathDB:YBR288C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKS6
    Summary
    Involved in Golgi to vacuole transport and protein targeting to vacuole. Part of AP-3 adaptor complex. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1) and AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APM3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (778012..779463, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene aminopeptidase Y Neighboring gene uncharacterized protein Neighboring gene Snf5p Neighboring gene Bsd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient ER exit and vacuole targeting of yeast Sna2p require two tyrosine-based sorting motifs. Renard HF, et al. Traffic, 2010 Jul 1. PMID 20406419
    2. Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein. Wen W, et al. Mol Biol Cell, 2006 Oct. PMID 16855025, Free PMC Article
    3. A microscopy-based kinetic analysis of yeast vacuolar protein sorting. Casler JC, et al. Elife, 2020 Jun 25. PMID 32584255, Free PMC Article
    4. Generation of null alleles for the functional analysis of six genes from the right arm of Saccharomyces cerevisiae chromosome II. Dueñas E, et al. Yeast, 1999 May. PMID 10341424
    5. The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. Stepp JD, et al. J Cell Biol, 1997 Dec 29. PMID 9412470, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apm3p
    NP_009847.4
    • Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      778012..779463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178636.4 → NP_009847.4  TPA: Apm3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009847.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQT3, P38153
      UniProtKB/TrEMBL
      A6ZLM6, B3LMM5, C7GMU4, N1P795
      Conserved Domains (1) summary
      cl10970
      Location:199 → 482
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38153.2

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