DUT1 bifunctional dITP/dUTP diphosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DUT1
Official Full Name: bifunctional dITP/dUTP diphosphatase
Primary source: SGD:S000000456
Locus tag: YBR252W
See related: AllianceGenome:SGD:S000000456; FungiDB:YBR252W; VEuPathDB:YBR252W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dITP diphosphatase activity and dUTP diphosphatase activity. Involved in dITP catabolic process and dUTP catabolic process. Located in cytoplasm and nucleus. Used to study cancer. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DUT1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (722611..723054)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure of DUT1 and site-directed mutagenesis support a role of the conserved Phe142 in the interaction with the uracil base.
Title: Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme.
Dut1 plays a central role in the prevention of the formation of endogenous DNA damage.
Title: dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dITP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dUTP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dUTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dUTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables dUTP diphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dITP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dUMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dUTP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUTP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dUTP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dUTP catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine deoxyribonucleoside triphosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: bifunctional dITP/dUTP diphosphatase

NP_009811.3

EC 3.6.1.23

Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

722611..723054

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178600.3 → NP_009811.3 TPA: bifunctional dITP/dUTP diphosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009811.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQP8, P33317

UniProtKB/TrEMBL

A6ZLJ1, B3LMR0, C7GMX9, D3UEZ9, G2W9Q5, N1P8T1

Conserved Domains (1) summary

TIGR00576
Location:9 → 146

dut; deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)