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    PGI1 glucose-6-phosphate isomerase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGI1
    Official Full Name
    glucose-6-phosphate isomerase
    Primary source
    SGD:S000000400
    Locus tag
    YBR196C
    See related
    AllianceGenome:SGD:S000000400; FungiDB:YBR196C; VEuPathDB:YBR196C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC30
    Summary
    Enables glucose-6-phosphate isomerase activity. Involved in gluconeogenesis and glycolytic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGI1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (612236..613900, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Aim4p Neighboring gene Msi1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic studies with a phosphoglucose isomerase mutant of Saccharomyces cerevisiae. Maitra PK, et al. Mol Gen Genet, 1977 Nov 4. PMID 340892
    2. Importance of product/reactant equilibration in the kinetics of the phosphoglucose isomerization reaction by differential stopped flow microcalorimetry. Stödeman M, et al. Anal Biochem, 2004 Jun 15. PMID 15158492
    3. Identification of the first fungal NADP-GAPDH from Kluyveromyces lactis. Verho R, et al. Biochemistry, 2002 Nov 19. PMID 12427047
    4. Multiple forms of yeast phosphoglucose isomerase. I. Resolution of the crystalline enzyme into three isoenzymes. Nakagawa Y, et al. J Biol Chem, 1967 Oct 25. PMID 6061419
    5. Physical and chemical properties of yeast phosphoglucose isomerase isoenzymes. Kempe TD, et al. J Biol Chem, 1974 Jul 25. PMID 4602031

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate isomerase
    NP_009755.1
    • Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      612236..613900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178544.1 → NP_009755.1  TPA: glucose-6-phosphate isomerase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009755.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQJ0, P12709
      UniProtKB/TrEMBL
      A6ZLD6, B3LMW6, B5VEE5, C7GKF5, D3UEU0, G2W9J7, N1PAU8
      Conserved Domains (1) summary
      PRK00179
      Location:12 → 553
      pgi; glucose-6-phosphate isomerase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12709.3

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