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    ARR1 Arr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARR1
    Official Full Name
    Arr1p
    Primary source
    SGD:S000006403
    Locus tag
    YPR199C
    See related
    AllianceGenome:SGD:S000006403; FungiDB:YPR199C; VEuPathDB:YPR199C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACR1; YAP8
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to arsenic-containing substance and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (938148..939032, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative maltose-responsive transcription factor Neighboring gene Sge1p Neighboring gene Arr2p Neighboring gene Arr3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity. Maciaszczyk-Dziubinska E, et al. Nucleic Acids Res, 2020 Jun 4. PMID 32356892, Free PMC Article
    2. Two residues in the basic region of the yeast transcription factor Yap8 are crucial for its DNA-binding specificity. Amaral C, et al. PLoS One, 2013. PMID 24358276, Free PMC Article
    3. Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8. Kumar NV, et al. Mol Cell Biol, 2015 Dec 28. PMID 26711267, Free PMC Article
    4. Yap8p activation in Saccharomyces cerevisiae under arsenic conditions. Menezes RA, et al. FEBS Lett, 2004 May 21. PMID 15147884
    5. One Hand Clapping: detection of condition-specific transcription factor interactions from genome-wide gene activity data. Dümcke S, et al. Nucleic Acids Res, 2012 Oct. PMID 22844089, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N-terminal tail of Yap8 directly interacts with DNA and stabilizes Yap8 binding to the 13 bp motif.
      Title: The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity.
    2. As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an active transcriptional regulator.
      Title: Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
    3. Leu26 is required for Yap8 binding to DNA and that this residue together with Asn31, hinder Yap1 response element recognition by Yap8, thus narrowing its DNA-binding specificity.
      Title: Two residues in the basic region of the yeast transcription factor Yap8 are crucial for its DNA-binding specificity.
    4. Yap8p requires distinct DNA-binding motifs to induce gene expression and propose that this fact contributed towards a separation of function between AP-1 proteins during evolution
      Title: Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.
    5. ARR1 is degraded by the ubiquitin-proteasome pathway in untreated cells, whereas arsenite-exposure results in its stabilization and gene activation.
      Title: Regulation of the arsenic-responsive transcription factor Yap8p involves the ubiquitin-proteasome pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to arsenic-containing substance HMP PubMed 
    involved_in cellular response to arsenic-containing substance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II HMP PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arr1p
    NP_015525.1
    • Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      938148..939032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184296.1 → NP_015525.1  TPA: Arr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J7, Q06596
      UniProtKB/TrEMBL
      B3LRH9, B5VTX6, C8ZJM8, N1NVM8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06596.1

    Gene LinkOut

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