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    ARR2 Arr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARR2
    Official Full Name
    Arr2p
    Primary source
    SGD:S000006404
    Locus tag
    YPR200C
    See related
    AllianceGenome:SGD:S000006404; FungiDB:YPR200C; VEuPathDB:YPR200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACR2
    Summary
    Enables arsenate reductase activity. Predicted to be involved in response to arsenic-containing substance. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARR2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (939279..939671, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Sge1p Neighboring gene Arr1p Neighboring gene Arr3p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. Mukhopadhyay R, et al. FEMS Microbiol Lett, 1998 Nov 1. PMID 9812373
    2. The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. Mukhopadhyay R, et al. J Biol Chem, 2001 Sep 14. PMID 11461905
    3. Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. Mukhopadhyay R, et al. J Biol Chem, 2003 Jul 4. PMID 12711608
    4. A novel arsenate reductase from the arsenic hyperaccumulating fern Pteris vittata. Ellis DR, et al. Plant Physiol, 2006 Aug. PMID 16766666, Free PMC Article
    5. Knocking out ACR2 does not affect arsenic redox status in Arabidopsis thaliana: implications for as detoxification and accumulation in plants. Liu W, et al. PLoS One, 2012. PMID 22879969, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables arsenate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arsenate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to arsenic-containing substance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Arr2p
    NP_015526.1
    • Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      939279..939671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184297.1 → NP_015526.1  TPA: Arr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J8, Q06597
      UniProtKB/TrEMBL
      A6ZX72, B3LRI0, C7GP78, C8ZJM9, G2WQ09, N1P2J4
      Conserved Domains (1) summary
      cd01531
      Location:2 → 119
      Acr2p; Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06597.1

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