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    AXL1 Axl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AXL1
    Official Full Name
    Axl1p
    Primary source
    SGD:S000006326
    Locus tag
    YPR122W
    See related
    AllianceGenome:SGD:S000006326; FungiDB:YPR122W; VEuPathDB:YPR122W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUS5; STE22
    Summary
    Enables metalloendopeptidase activity. Involved in axial cellular bud site selection; cytogamy; and peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion. Located in cellular bud neck and mating projection tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AXL1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (782045..785671)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Cys Neighboring gene putative phosphomethylpyrimidine kinase Neighboring gene high-affinity Cu transporter CTR1 Neighboring gene Ylh47p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection. Adames N, et al. Science, 1995 Oct 20. PMID 7569998
    2. A common genetic system for functional studies of pitrilysin and related M16A proteases. Alper BJ, et al. Biochem J, 2006 Aug 15. PMID 16722821, Free PMC Article
    3. Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme. Kim S, et al. J Biol Chem, 2005 Jul 29. PMID 15944156
    4. Combining mutations in the incoming and outgoing pheromone signal pathways causes a synergistic mating defect in Saccharomyces cerevisiae. Giot L, et al. Yeast, 1999 Jun 30. PMID 10398345
    5. Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing. Meacham GC, et al. J Biol Chem, 1999 Nov 26. PMID 10567418

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Axl1p
    NP_015447.1
    • Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      782045..785671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184219.1 → NP_015447.1  TPA: Axl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4C1, P40851
      UniProtKB/TrEMBL
      A6ZX03, B3LK86, C7GLI5, C8ZJE4, N1NVL3
      Conserved Domains (1) summary
      COG1025
      Location:1 → 1111
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40851.2

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