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    LTP1 tyrosine protein phosphatase LTP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LTP1
    Official Full Name
    tyrosine protein phosphatase LTP1
    Primary source
    SGD:S000006277
    Locus tag
    YPR073C
    See related
    AllianceGenome:SGD:S000006277; FungiDB:YPR073C; VEuPathDB:YPR073C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tyrosine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LTP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (691933..692418, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene CCR4-NOT core subunit NOT5 Neighboring gene transketolase TKL1 Neighboring gene Opy2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase. Ostanin K, et al. J Biol Chem, 1995 Aug 4. PMID 7629177
    2. Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate. Wang S, et al. Biochemistry, 2000 Feb 29. PMID 10684639
    3. Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1. Paoli P, et al. Biochim Biophys Acta, 2007 May. PMID 17296269
    4. The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1. Magherini F, et al. Biochem Biophys Res Commun, 2004 Aug 20. PMID 15358193
    5. Identification of putative negative regulators of yeast signaling through a screening for protein phosphatases acting on cell wall integrity and mating MAPK pathways. Sacristán-Reviriego A, et al. Fungal Genet Biol, 2015 Apr. PMID 25736922

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The site-directed mutagenesis of two aromatic residues lining the active site pocket of LTP1 was studied.
      Title: Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    tyrosine protein phosphatase LTP1
    NP_015398.1
    • Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      691933..692418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184170.1 → NP_015398.1  TPA: tyrosine protein phosphatase LTP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W477, P40347
      UniProtKB/TrEMBL
      A6ZWW0, B3LLC6, C7GXZ9, C8ZJ98, G2WPP5, N1NWD4
      Conserved Domains (1) summary
      cd00115
      Location:9 → 158
      LMWP; Low molecular weight phosphatase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40347.1

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