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    ELP3 Elongator subunit ELP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856019, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ELP3
    Official Full Name
    Elongator subunit ELP3
    Primary source
    SGD:S000006007
    Locus tag
    YPL086C
    See related
    AllianceGenome:SGD:S000006007; FungiDB:YPL086C; VEuPathDB:YPL086C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HPA1; KAT9; KTI8; TOT3
    Summary
    Predicted to enable tRNA uridine(34) acetyltransferase activity. Involved in tRNA wobble uridine modification. Located in cytoplasm and nucleus. Part of elongator holoenzyme complex. Orthologous to human ELP3 (elongator acetyltransferase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ELP3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (384773..386446, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase superfamily protein Neighboring gene alkaline dihydroceramidase Neighboring gene Sec16p Neighboring gene Bro1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of ncm(5) and mcm(5) wobble uridine side chains results in an altered metabolic profile. Karlsborn T, et al. Metabolomics, 2016. PMID 27738410, Free PMC Article
    2. [The elp3 subunit of human elongator complex ignificantly complemented the growth defects of yeast elp3delta strain]. Li F, et al. Shi Yan Sheng Wu Xue Bao, 2005 Oct. PMID 16363116
    3. [Identification and application of yeast histone acetyltransferases Elp3 polyclonal antibody]. Li F, et al. Sheng Wu Gong Cheng Xue Bao, 2009 Aug. PMID 19938466
    4. The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast. Li F, et al. Mol Genet Genomics, 2005 May. PMID 15902492
    5. Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast. Pollo-Oliveira L, et al. Biomolecules, 2020 Feb 18. PMID 32085421, Free PMC Article

    See all (176) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.
      Title: Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.
    2. both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes
      Title: Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae.
    3. We present our working model in which Elp3/Gcn5 and the APC work together to facilitate passage through mitosis and G(1). To progress into S, we propose that at least Gcn5 must then be targeted for degradation in an APC-dependent fashion.
      Title: The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.
    4. Results conclude that yeast and plant Elongator (elp3/ELO3) share tRNA modification roles and propose that this function might be conserved in Elongator from all eukaryotic kingdoms of life.
      Title: Elongator function in tRNA wobble uridine modification is conserved between yeast and plants.
    5. report an interaction between the Elongator histone acetyltransferase and the proliferating cell nuclear antigen. Cells lacking Elp3 and are sensitive to the DNA replication inhibitor hydroxyurea and the damaging agent methyl methanesulfonate.
      Title: The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents.
    6. the Elp3 FeS cluster is essential for normal Elongator function in vivo primarily as a structural, rather than catalytic, domain.
      Title: An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.
    7. The HATs (histone acetyltransferases) Gcn5 (general control non-derepressible 5) and Elp3 (elongation protein 3) modulated hsp70 gene transcription by affecting the acetylation status of histone H3.
      Title: Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast.
    8. close physical and functional relationship between Elongator and the highly conserved Kti12 protein
      Title: Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA uridine(34) acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA uridine(34) acetyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongator subunit ELP3
    NP_015239.1
    • Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      384773..386446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183900.1 → NP_015239.1  TPA: Elongator subunit ELP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3T1, Q02908
      UniProtKB/TrEMBL
      A6ZWG5, B3LKY6, B5VT79, C7GVE6, C8ZIU4, G2WP95, N1NX70
      Conserved Domains (1) summary
      TIGR01211
      Location:32 → 557
      ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02908.1

    Gene LinkOut

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