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    DAP1 Dap1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAP1
    Official Full Name
    Dap1p
    Primary source
    SGD:S000006091
    Locus tag
    YPL170W
    See related
    AllianceGenome:SGD:S000006091; FungiDB:YPL170W; VEuPathDB:YPL170W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables heme binding activity. Involved in regulation of ergosterol biosynthetic process. Located in endosome. Orthologous to human PGRMC1 (progesterone receptor membrane component 1) and PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (228314..228772)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protoheme IX farnesyltransferase Neighboring gene NADPH dehydrogenase Neighboring gene Mex67p Neighboring gene Mrx4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mallory JC, et al. Mol Cell Biol, 2005 Mar. PMID 15713626, Free PMC Article
    2. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. Hand RA, et al. Eukaryot Cell, 2003 Apr. PMID 12684380, Free PMC Article
    3. Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Thompson AM, et al. Biochemistry, 2007 Dec 18. PMID 18031064, Free PMC Article
    4. Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Ghosh K, et al. Biochemistry, 2005 Dec 20. PMID 16342963, Free PMC Article
    5. Global analysis of the yeast knockout phenome. Turco G, et al. Sci Adv, 2023 May 26. PMID 37235661, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that both wild-type and mutant proteins bind heme in a 1:1 fashion, possessing tight ferric heme affinities and its measured reduction potential was found to be similar to that of other monotyrosinate hemoproteins.
      Title: Measurement of the heme affinity for yeast dap1p, and its importance in cellular function.
    2. Loss of Dap1 is suppressed by elevated levels of Erg11 but not by increased heme biosynthesis.
      Title: Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.
    3. spectroscopic and biochemical characterization of binding to heme
      Title: Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of ergosterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dap1p
    NP_015155.1
    • Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      228314..228772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183984.1 → NP_015155.1  TPA: Dap1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015155.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3J8, Q12091
      UniProtKB/TrEMBL
      A6ZW83, B3LKQ8, C7GJC1, C8ZIK8, G2WP12, N1NW05
      Conserved Domains (1) summary
      pfam00173
      Location:46 → 108
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12091.1

    Gene LinkOut

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