U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RSA1 Rsa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855908, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RSA1
    Official Full Name
    Rsa1p
    Primary source
    SGD:S000006114
    Locus tag
    YPL193W
    See related
    AllianceGenome:SGD:S000006114; FungiDB:YPL193W; VEuPathDB:YPL193W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in box C/D snoRNP assembly and ribosomal large subunit assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RSA1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (181403..182548)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Apl5p Neighboring gene Ddc1p Neighboring gene pheromone-regulated protein PRM3 Neighboring gene ubiquitinyl hydrolase 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Synthetic lethality with conditional dbp6 alleles identifies rsa1p, a nucleoplasmic protein involved in the assembly of 60S ribosomal subunits. Kressler D, et al. Mol Cell Biol, 1999 Dec. PMID 10567587, Free PMC Article
    2. RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling. DeLabre ML, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997090
    3. Box C/D snoRNPs: solid-state NMR fingerprint of an early-stage 50 kDa assembly intermediate. Chagot ME, et al. Biomol NMR Assign, 2020 Apr. PMID 32030621
    4. Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. Quinternet M, et al. J Mol Biol, 2015 Aug 28. PMID 26210662
    5. Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly. Rothé B, et al. Nucleic Acids Res, 2017 Jul 7. PMID 28505348, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rsa1p enhances Snu13p binding on the U3 box C/D small nucleolar RNA which is one key element of 90S pre-ribosome.
      Title: Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly.
    2. Thus study identified the protein Hit1 as a novel Rsa1p-interacting partner involved in C/D snoRNP assembly.
      Title: Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.
    3. Identification of residues needed for Snu13p and Rsa1p interaction.
      Title: Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Rsa1p
    NP_015131.1
    • Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      181403..182548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184007.1 → NP_015131.1  TPA: Rsa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015131.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H5, Q08932
      UniProtKB/TrEMBL
      A6ZW60, B3LKN5, B5VSY4, C7GTT1, C8ZII6, N1NVN6
      Conserved Domains (1) summary
      pfam10453
      Location:224 → 274
      NUFIP1; Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08932.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools