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    FLC1 flavin adenine dinucleotide transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FLC1
    Official Full Name
    flavin adenine dinucleotide transporter
    Primary source
    SGD:S000006142
    Locus tag
    YPL221W
    See related
    AllianceGenome:SGD:S000006142; FungiDB:YPL221W; VEuPathDB:YPL221W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables FAD transmembrane transporter activity. Involved in several processes, including FAD transport; fungal-type cell wall biogenesis; and protein folding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FLC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (133043..135424)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Gre1p Neighboring gene Fmp40p Neighboring gene ribosomal 60S subunit protein L1A Neighboring gene Pcl8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Bop3 confers resistance to methylmercury in Saccharomyces cerevisiae through interaction with other proteins such as Fkh1, Rts1, and Msn2. Hwang GW, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796894
    2. Hypotonic stress-induced calcium signaling in Saccharomyces cerevisiae involves TRP-like transporters on the endoplasmic reticulum membrane. Rigamonti M, et al. Cell Calcium, 2015 Feb. PMID 25573187
    3. A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. Protchenko O, et al. J Biol Chem, 2006 Jul 28. PMID 16717099
    4. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article
    5. Mapping the functional yeast ABC transporter interactome. Snider J, et al. Nat Chem Biol, 2013 Sep. PMID 23831759, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FAD transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FAD transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FAD transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin adenine dinucleotide transporter
    NP_015103.1
    • Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      133043..135424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184035.1 → NP_015103.1  TPA: flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3E9, Q08967
      UniProtKB/TrEMBL
      A6ZW34, B3LKK9, B5VSW0, N1NXX9
      Conserved Domains (2) summary
      pfam06011
      Location:166 → 597
      TRP; Transient receptor potential (TRP) ion channel
      pfam14558
      Location:26 → 161
      TRP_N; ML-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08967.1

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