IQG1 Iqg1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IQG1
Official Full Name: Iqg1p
Primary source: SGD:S000006163
Locus tag: YPL242C
See related: AllianceGenome:SGD:S000006163; FungiDB:YPL242C; VEuPathDB:YPL242C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CYK1
Summary: Enables calmodulin binding activity and cytoskeletal protein binding activity. Involved in mitotic actomyosin contractile ring assembly actin filament organization; protein localization to cell division site; and regulation of mitotic actomyosin contractile ring contraction. Located in cellular bud neck contractile ring. Part of MIH complex. Orthologous to several human genes including IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See IQG1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (90622..95109, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dephosphorylation of Iqg1 by Cdc14 regulates cytokinesis in budding yeast
Title: Dephosphorylation of Iqg1 by Cdc14 regulates cytokinesis in budding yeast.
The Cdk1-dependent phosphorylation state of Iqg1 is a determining factor in the timing of bud neck localization of both Iqg1 and actin.
Title: Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.
Interacts with Cmd1p (calmodulin), Mlc1p (a myosin essential light chain) and Cdc42p (a small GTPase) in vivo.
Title: Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay.
compromise of APC/C function allows the accumulation of Iqg1p, which then promotes actomyosin-ring-independent cytokinesis at least in part by activation of Cyk3p
Title: Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.
Analysis of the synthetic lethal phenotypes reveals that Iqg1p functions in combination with the MEN components for cytokinesis and re-polarization of the actin cytoskeleton.
Title: IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin II heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin II light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell division site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MIH complex	IDA Inferred from Direct Assay more info	PubMed
part_of MIH complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in mitotic actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Iqg1p

NP_015082.1

Actin filament binding protein that enhances actin ring formation; IQGAP family member required for assembly and contraction of the AMR, prior to cytokinesis; localizes to the contractile ring during anaphase in an Mlc1p-dependent manner, recruiting Myo1p and Hof1p to the site, and promoting cytokinetic core complex assembly; specifies bud-site selection, localizing axial markers Bud4p and Cdc12p; regulated by Cdc28p; relocalizes from the bud neck to the cytoplasm upon replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

90622..95109 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184056.1 → NP_015082.1 TPA: Iqg1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015082.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3C9, Q12280

UniProtKB/TrEMBL

G2WNU4, N1NWD8

Conserved Domains (1) summary

COG5261
Location:1 → 1494

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]