YAR1 Yar1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YAR1
Official Full Name: Yar1p
Primary source: SGD:S000006160
Locus tag: YPL239W
See related: AllianceGenome:SGD:S000006160; FungiDB:YPL239W; VEuPathDB:YPL239W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables unfolded protein binding activity. Involved in several processes, including cellular response to oxidative stress; response to osmotic stress; and ribosome biogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

binding of Yar1 to one N-domain and binding of Kap60 to the second N-domain of dimerized Rps3 orchestrates import and protection of the ribosomal protein
Title: Nuclear import of dimerized ribosomal protein Rps3 in complex with its chaperone Yar1.
Yar1 is a specific chaperone for Rps3, which serves to keep Rps3 soluble until its incorporation into the pre-ribosome
Title: Yar1 protects the ribosomal protein Rps3 from aggregation.
nonessential role in 40S ribosomal subunit production
Title: Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal small subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MBF transcription complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SBF transcription complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IGI Inferred from Genetic Interaction more info	PubMed

NP_015085.1

Nucleocytoplasmic shuttling assembly chaperone; co-translationally associates with nascent Rps3p in the cytoplasm and delivers it to pre-ribosomal subunits in the nucleus; required for 40S ribosomal subunit nuclear export, biogenesis and adaptation to osmotic and oxidative stress; contains ankyrin-repeats; expression repressed by heat shock

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