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    FSF1 Fsf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FSF1
    Official Full Name
    Fsf1p
    Primary source
    SGD:S000005797
    Locus tag
    YOR271C
    See related
    AllianceGenome:SGD:S000005797; FungiDB:YOR271C; VEuPathDB:YOR271C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Acts upstream of or within cellular response to anoxia. Located in mitochondrion. Orthologous to several human genes including SFXN5 (sideroflexin 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FSF1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (831059..832042, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pac1p Neighboring gene H(+)-transporting V0 sector ATPase subunit a Neighboring gene ncRNA Neighboring gene Ytm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In silico analyses of Fsf1 sequences, a new group of fungal proteins orthologous to the metazoan sideroblastic anemia-related sideroflexin family. Miotto G, et al. Fungal Genet Biol, 2007 Aug. PMID 17240176
    2. Comparative genomics of transcriptional regulation in yeasts and its application to identification of a candidate alpha-isopropylmalate transporter. Kovaleva GY, et al. J Bioinform Comput Biol, 2006 Oct. PMID 17099937
    3. A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. Enriquez-Hesles E, et al. J Biol Chem, 2021 Jan-Jun. PMID 33243834, Free PMC Article
    4. A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Stevenson LF, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274415, Free PMC Article
    5. Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane. Claypool SM, et al. J Cell Biol, 2008 Sep 8. PMID 18779372, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to anoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fsf1p
    NP_014914.1
    • Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      831059..832042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183690.1 → NP_014914.1  TPA: Fsf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2X1, Q12029
      UniProtKB/TrEMBL
      A6ZPA8, B3LJT7, B5VSF0, C7GWB9, C8ZH21, G2WND9, N1NVX7
      Conserved Domains (1) summary
      pfam03820
      Location:10 → 327
      Mtc; Tricarboxylate carrier
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12029.1

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