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    HUB1 ubiquitin-like protein HUB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HUB1
    Official Full Name
    ubiquitin-like protein HUB1
    Primary source
    SGD:S000007251
    Locus tag
    YNR032C-A
    See related
    AllianceGenome:SGD:S000007251; FungiDB:YNR032C-A; VEuPathDB:YNR032C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tag activity. Involved in several processes, including cell morphogenesis involved in conjugation with cellular fusion; mRNA splicing, via spliceosome; and positive regulation of RNA splicing. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBL5 (ubiquitin like 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HUB1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (687243..687464, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase SSK2 Neighboring gene putative serine/threonine-protein kinase PPG1 Neighboring gene 4-amino-4-deoxychorismate synthase Neighboring gene Sol1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. Lüders J, et al. EMBO Rep, 2003 Dec. PMID 14608371, Free PMC Article
    2. Role of a ubiquitin-like modification in polarized morphogenesis. Dittmar GA, et al. Science, 2002 Mar 29. PMID 11923536
    3. The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. Ammon T, et al. J Mol Cell Biol, 2014 Aug. PMID 24872507, Free PMC Article
    4. Structural analysis of UBL5, a novel ubiquitin-like modifier. McNally T, et al. Protein Sci, 2003 Jul. PMID 12824502, Free PMC Article
    5. Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1. Karaduman R, et al. Mol Cell, 2017 Aug 3. PMID 28712727

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
      Title: ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
    2. Hub1 mediates enhanced, but error-prone splicing, a mechanism that is tightly controlled by a feedback loop of PRP5 cryptic splicing activation.
      Title: Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein modification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like protein HUB1
    NP_014430.1
    • Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      687243..687464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184344.1 → NP_014430.1  TPA: ubiquitin-like protein HUB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1K7, Q6Q546
      UniProtKB/TrEMBL
      A6ZSA6, B3LPL1, C7GLM5, C8ZFR0, N1NXS3
      Conserved Domains (1) summary
      cd01791
      Location:1 → 71
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q546.2

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