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    SMM1 tRNA-dihydrouridine(20) synthase (NAD(+)) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMM1
    Official Full Name
    tRNA-dihydrouridine(20) synthase (NAD(+))
    Primary source
    SGD:S000005298
    Locus tag
    YNR015W
    See related
    AllianceGenome:SGD:S000005298; FungiDB:YNR015W; VEuPathDB:YNR015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DUS2
    Summary
    Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMM1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (653387..654541)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pho91p Neighboring gene uncharacterized protein Neighboring gene acetyl-CoA carboxylase ACC1 Neighboring gene protein transporter TIM23

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Additional copies of the mitochondrial Ef-Tu and aspartyl-tRNA synthetase genes can compensate for a mutation affecting the maturation of the mitochondrial tRNAAsp. Rinaldi T, et al. Curr Genet, 1997 Jun. PMID 9211792
    2. Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. Rider LW, et al. J Biol Chem, 2009 Apr 17. PMID 19139092, Free PMC Article
    3. FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. Chen X, et al. Nat Commun, 2020 Feb 13. PMID 32054832, Free PMC Article
    4. Nucleo-mitochondrial interactions in Saccharomyces cerevisiae: characterization of a nuclear gene suppressing a defect in mitochondrial tRNA(Asp) processing. Rinaldi T, et al. Gene, 2003 Jan 16. PMID 12559567
    5. An extended dsRBD is required for post-transcriptional modification in human tRNAs. Bou-Nader C, et al. Nucleic Acids Res, 2015 Oct 30. PMID 26429968, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA-dihydrouridine20 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA dihydrouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(20) synthase (NAD(+))
    NP_014412.1
    • Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of the D loop of cytoplasmic pre-tRNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      653387..654541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183192.1 → NP_014412.1  TPA: tRNA-dihydrouridine(20) synthase (NAD(+)) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1J0, P53720
      UniProtKB/TrEMBL
      A6ZS89, B3LPM7, B5VR46, C7GLP0, G2WL72, N1NWS7
      Conserved Domains (1) summary
      cl21457
      Location:31 → 355
      TIM; TIM-like beta/alpha barrel domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53720.1

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