OGG1 8-oxoguanine glycosylase OGG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: OGG1
Official Full Name: 8-oxoguanine glycosylase OGG1
Primary source: SGD:S000004525
Locus tag: YML060W
See related: AllianceGenome:SGD:S000004525; FungiDB:YML060W; VEuPathDB:YML060W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in base-excision repair, AP site formation; error-free translesion synthesis; and telomere maintenance via telomerase. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See OGG1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (151871..153001)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Saccharomyces cerevisiae ablation of Ogg1p leads to an increase in oxidized guanine level in telomeric DNA.
Title: Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast.
Ogg1 prevents poly(GT) tract instability in the mitochondrial genome
Title: Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome.
The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed.
Title: Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidized base lesion DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info
enables oxidized purine nucleobase lesion DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair, AP site formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair, AP site formation	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair, AP site formation	IEA Inferred from Electronic Annotation more info
involved_in error-free translesion synthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 8-oxoguanine glycosylase OGG1

NP_013651.1

EC 4.2.99.18

Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

151871..153001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182419.1 → NP_013651.1 TPA: 8-oxoguanine glycosylase OGG1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013651.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZB3, P53397

UniProtKB/TrEMBL

B3LLJ5, C7GVZ6, C8ZEE5, G2WJZ5, N1NYZ7

Conserved Domains (1) summary

TIGR00588
Location:1 → 328

ogg; 8-oxoguanine DNA-glycosylase (ogg)