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    NGL3 3'-5' poly(A) RNA exonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NGL3
    Official Full Name
    3'-5' poly(A) RNA exonuclease
    Primary source
    SGD:S000004587
    Locus tag
    YML118W
    See related
    AllianceGenome:SGD:S000004587; FungiDB:YML118W; VEuPathDB:YML118W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables poly(A)-specific ribonuclease activity. Involved in polyadenylation-dependent RNA catabolic process. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NGL3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (32334..33851)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene NADH-ubiquinone reductase (H(+)-translocating) NDI1 Neighboring gene uncharacterized protein Neighboring gene Nab6p Neighboring gene borate transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases. Feddersen A, et al. Nucleic Acids Res, 2012 Jan. PMID 21965533, Free PMC Article
    2. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. Faber AW, et al. RNA, 2002 Sep. PMID 12358428, Free PMC Article
    3. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. Dupressoir A, et al. BMC Genomics, 2001. PMID 11747467, Free PMC Article
    4. Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1. Milliman EJ, et al. PLoS One, 2012. PMID 22953000, Free PMC Article
    5. Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. Vizeacoumar FJ, et al. J Cell Biol, 2010 Jan 11. PMID 20065090, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ngl3p is a functional 3'-5' exonuclease most active at slightly acidic conditions.
      Title: Saccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in polyadenylation-dependent RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    3'-5' poly(A) RNA exonuclease
    NP_013588.1
    • 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      32334..33851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182481.1 → NP_013588.1  TPA: 3'-5' poly(A) RNA exonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0G6, Q03210, Q03733
      UniProtKB/TrEMBL
      A6ZLU6, B3LLE1, C7GVA0, C8ZE84, N1P5B4
      Conserved Domains (1) summary
      COG5239
      Location:67 → 496
      CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03210.1

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