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    NAB6 Nab6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NAB6
    Official Full Name
    Nab6p
    Primary source
    SGD:S000004585
    Locus tag
    YML117W
    See related
    AllianceGenome:SGD:S000004585; FungiDB:YML117W; VEuPathDB:YML117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and cellular response to cell wall damage. Located in cytoplasmic stress granule. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NAB6 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (34243..37647)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene 3'-5' poly(A) RNA exonuclease Neighboring gene borate transporter Neighboring gene Van1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling of a Saccharomyces cerevisiae mutant with a constitutively activated Ras/cAMP pathway. Jones DL, et al. Physiol Genomics, 2003 Dec 16. PMID 14570984
    2. Enhancement of protein production via the strong DIT1 terminator and two RNA-binding proteins in Saccharomyces cerevisiae. Ito Y, et al. Sci Rep, 2016 Nov 15. PMID 27845367, Free PMC Article
    3. Mitochondrial fission proteins Fis1 and Mdv1, but not Dnm1, play a role in maintenance of heteroplasmy in budding yeast. Bradshaw E, et al. FEBS Lett, 2012 Apr 24. PMID 22575664
    4. Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae. Ezeokonkwo C, et al. FEBS Lett, 2012 Apr 24. PMID 22575652, Free PMC Article
    5. A novel plasmid-based microarray screen identifies suppressors of rrp6Delta in Saccharomyces cerevisiae. Abruzzi K, et al. Mol Cell Biol, 2007 Feb. PMID 17101774, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in 3'-UTR-mediated mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cell wall damage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to cell wall damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nab6p
    NP_013589.1
    • mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and stabilizes these mRNAs, acting in parallel to cell wall integrity signaling to maintain expression of cell wall genes during stress; acts antagonistically to Nab6p; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      34243..37647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182479.1 → NP_013589.1  TPA: Nab6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0G7, Q03735
      UniProtKB/TrEMBL
      N1NYL6
      Conserved Domains (4) summary
      cd12521
      Location:652 → 725
      RRM3_MRN1; RNA recognition motif 3 of RNA-binding protein MRN1 and similar proteins
      pfam10378
      Location:60 → 104
      RRM; Putative RRM domain
      pfam10567
      Location:199 → 560
      Nab6_mRNP_bdg; RNA-recognition motif
      cl17169
      Location:741 → 860
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03735.1

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