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    BUL2 ubiquitin-ubiquitin ligase BUL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BUL2
    Official Full Name
    ubiquitin-ubiquitin ligase BUL2
    Primary source
    SGD:S000004579
    Locus tag
    YML111W
    See related
    AllianceGenome:SGD:S000004579; FungiDB:YML111W; VEuPathDB:YML111W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-ubiquitin ligase activity. Involved in protein monoubiquitination and protein polyubiquitination. Located in cytoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BUL2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (46942..49704)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Dat1p Neighboring gene Ctk3p Neighboring gene 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase Neighboring gene Zds2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2. Watanabe D, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25998383
    2. The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Yashiroda H, et al. Gene, 1998 Dec 28. PMID 9931424
    3. Yeast Npi3/Bro1 is involved in ubiquitin-dependent control of permease trafficking. Springael JY, et al. FEBS Lett, 2002 Apr 24. PMID 12062418
    4. Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1. Soetens O, et al. J Biol Chem, 2001 Nov 23. PMID 11500494
    5. Rsp5-Bul1/2 complex is necessary for the HSE-mediated gene expression in budding yeast. Kaida D, et al. Biochem Biophys Res Commun, 2003 Jul 11. PMID 12821147

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in Rsp5p-Bul1-Bil2p ubiquitin ligase complex favors initial growth of autotrophic in synthetic grape must.
      Title: An impaired ubiquitin ligase complex favors initial growth of auxotrophic yeast strains in synthetic grape must.
    2. While rsp5(T255A), RSP5(T357A), and rsp5(T413A) impaired the interaction of Rsp5 with Bul1, the RSP5(T357A) mutation specifically augmented the interaction with Bul2.
      Title: Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2.
    3. Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors.
      Title: Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors.
    4. Identification of a polymorphism in BUL2 in this outbred yeast population revealed a link among cellular amino acid availability, chronological lifespan, and telomere length control.
      Title: Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
    5. Gln3-mediated transcription activated by nitrogen signal transduction is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
      Title: Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-ubiquitin ligase BUL2
    NP_013596.1
    • Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      46942..49704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182473.1 → NP_013596.1  TPA: ubiquitin-ubiquitin ligase BUL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0H3, Q03758
      UniProtKB/TrEMBL
      A6ZLV3, B3LLE8, C7GV93, N1NYA8
      Conserved Domains (2) summary
      pfam04426
      Location:646 → 918
      Bul1_C; Bul1 C-terminus
      pfam04425
      Location:87 → 525
      Bul1_N; Bul1 N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03758.1

    Gene LinkOut

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