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    IKI3 Elongator subunit IKI3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IKI3
    Official Full Name
    Elongator subunit IKI3
    Primary source
    SGD:S000004376
    Locus tag
    YLR384C
    See related
    AllianceGenome:SGD:S000004376; FungiDB:YLR384C; VEuPathDB:YLR384C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ELP1; KTI7; TOT1
    Summary
    Enables tRNA binding activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Part of elongator holoenzyme complex. Used to study Riley-Day syndrome. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IKI3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (888851..892900, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene leucine--tRNA ligase NAM2 Neighboring gene DNA repair protein SMC6 Neighboring gene Swc7p Neighboring gene Vac14p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Kishida M, et al. Biosci Biotechnol Biochem, 1996 May. PMID 8704309
    2. Characterization of IKI1 and IKI3 genes conferring pGKL killer sensitivity on Saccharomyces cerevisiae. Yajima H, et al. Biosci Biotechnol Biochem, 1997 Apr. PMID 9145530
    3. Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana. Chen Z, et al. Mol Cell Biol, 2006 Sep. PMID 16943431, Free PMC Article
    4. Elongator function in tRNA wobble uridine modification is conserved between yeast and plants. Mehlgarten C, et al. Mol Microbiol, 2010 Jun 1. PMID 20398216, Free PMC Article
    5. Molecular basis of tRNA recognition by the Elongator complex. Dauden MI, et al. Sci Adv, 2019 Jul. PMID 31309145, Free PMC Article

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminal truncation of Elp1p is not likely to regulate elongator complex activity.
      Title: Yeast Elongator protein Elp1p does not undergo proteolytic processing in exponentially growing cells.
    2. The formation of the Elp1 dimer contributes to its stability in vitro and in vivo and is required for the assembly of yeast Elongator complexes.
      Title: Dimerization of elongator protein 1 is essential for Elongator complex assembly.
    3. Thus the conserved basic region in Elp1 may be essential for tRNA wobble uridine modification by acting as tRNA binding motif.
      Title: A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex.
    4. These data suggest that rather than directly targeting Elp1, the Hrr25 kinase indirectly affects Elp1 phosphorylation states through control of Sit4-dependent dephosphorylation of Elp1.
      Title: Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongator subunit IKI3
    NP_013488.3
    • Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      888851..892900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182273.3 → NP_013488.3  TPA: Elongator subunit IKI3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013488.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ19, O00036, Q06706
      UniProtKB/TrEMBL
      A7A1Q9
      Conserved Domains (2) summary
      COG5290
      Location:18 → 1348
      COG5290; IkappaB kinase complex, IKAP component [Transcription]
      sd00006
      Location:1004 → 1034
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06706.1

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