dlx1a distal-less homeobox 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlx1aprovided by ZNC
Official Full Name: distal-less homeobox 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-48
See related: Ensembl:ENSDARG00000013125 AllianceGenome:ZFIN:ZDB-GENE-990415-48
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlx1; zgc:111939
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cartilage development and embryonic viscerocranium morphogenesis. Predicted to be located in nucleus. Is expressed in brain; pharyngeal arch; and ventricular zone. Orthologous to human DLX1 (distal-less homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (3388099..3390106)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (3413972..3419326)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that dlx1a/2a and dlx5a/6a expressing progenitors give rise, for the most part, to small populations of cells which constitute only a small proportion of GABAergic cells in the adult brain tissue.
Title: Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain.
dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification
Title: The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
embryos injected with dlx1a and dlx2a but not dlx1a MOs exhibit reduced and dysmorphic arch cartilage elements.
Title: Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of photoreceptor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of amacrine cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Dlx1a

Names: DLX-1; distal-less homeobox gene 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131305.1 → NP_571380.1 homeobox protein Dlx1a

See identical proteins and their annotated locations for NP_571380.1

Status: PROVISIONAL

Source sequence(s)

U67842

UniProtKB/Swiss-Prot

Q567K7, Q98875

Related

ENSDARP00000011033.5, ENSDART00000019910.8

Conserved Domains (2) summary

COG5576
Location:124 → 233

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:131 → 184

Homeobox; Homeobox domain