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    nfixb nuclear factor I/Xb [ Danio rerio (zebrafish) ]

    Gene ID: 678521, updated on 4-Jan-2025

    Summary

    Official Symbol
    nfixbprovided by ZNC
    Official Full Name
    nuclear factor I/Xbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-5000
    See related
    Ensembl:ENSDARG00000061836 AllianceGenome:ZFIN:ZDB-GENE-060421-5000
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136878
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within DNA replication and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in dorsal telencephalon; midbrain; muscle; and telencephalon. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See nfixb in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (14749593..15064157)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (14617789..14914357)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zgc:158403 Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene uncharacterized LOC110439336 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene exportin 6 Neighboring gene adenine nucleotide translocase lysine methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC136878

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    Component Evidence Code Pubs
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040248.1NP_001035338.1  nuclear factor I/Xb

      See identical proteins and their annotated locations for NP_001035338.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115305
      UniProtKB/TrEMBL
      A0A8M1N8M6, A0A8M3B0T9, Q1RLS5
      Related
      ENSDARP00000084668.3, ENSDART00000090235.5
      Conserved Domains (3) summary
      cl00055
      Location:88192
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:233417
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3066
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      14749593..15064157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217605.1XP_068073706.1  nuclear factor I/Xb isoform X2

      UniProtKB/TrEMBL
      A0A8M3AQD4
    2. XM_068217604.1XP_068073705.1  nuclear factor I/Xb isoform X1

      UniProtKB/TrEMBL
      A0A8M3AQD4
    3. XM_068217609.1XP_068073710.1  nuclear factor I/Xb isoform X5

      UniProtKB/TrEMBL
      A0A8M3AXV2
    4. XM_068217618.1XP_068073719.1  nuclear factor I/Xb isoform X15

      UniProtKB/TrEMBL
      A0A8M3AQR5
    5. XM_068217607.1XP_068073708.1  nuclear factor I/Xb isoform X3

      UniProtKB/TrEMBL
      A0A8M3B860
    6. XM_068217608.1XP_068073709.1  nuclear factor I/Xb isoform X4

      UniProtKB/TrEMBL
      A0A8M3B0T6
    7. XM_068217610.1XP_068073711.1  nuclear factor I/Xb isoform X6

      UniProtKB/TrEMBL
      A0A8M3AXV2
    8. XM_068217612.1XP_068073713.1  nuclear factor I/Xb isoform X8

      UniProtKB/TrEMBL
      A0A8M3B863
    9. XM_068217611.1XP_068073712.1  nuclear factor I/Xb isoform X7

      UniProtKB/TrEMBL
      A0A8M3AQD9
    10. XM_068217619.1XP_068073720.1  nuclear factor I/Xb isoform X16

      UniProtKB/TrEMBL
      A0A8M3B0T9
    11. XM_068217617.1XP_068073718.1  nuclear factor I/Xb isoform X14

      UniProtKB/TrEMBL
      A0A8M3B0T9
    12. XM_068217616.1XP_068073717.1  nuclear factor I/Xb isoform X13

      UniProtKB/TrEMBL
      A0A8M3B0T9
    13. XM_009299287.4XP_009297562.1  nuclear factor I/Xb isoform X10

      UniProtKB/TrEMBL
      A0A8M3AQD4, A0A8M3AQR1
      Conserved Domains (3) summary
      cl00055
      Location:88192
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:233556
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3066
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    14. XM_005163820.5XP_005163877.1  nuclear factor I/Xb isoform X11

      UniProtKB/TrEMBL
      A0A8M2BBB5, A0A8M3AQD4
      Conserved Domains (3) summary
      cl00055
      Location:68172
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:213536
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:846
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    15. XM_005163822.5XP_005163879.1  nuclear factor I/Xb isoform X12

      UniProtKB/TrEMBL
      A0A8M2BAY5, A0A8M3AQD4
      Conserved Domains (3) summary
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:205528
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:138
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    16. XM_009299284.4XP_009297559.1  nuclear factor I/Xb isoform X9

      UniProtKB/TrEMBL
      A0A8M3AQD4, A0A8M3AXU6
      Conserved Domains (3) summary
      cl00055
      Location:106210
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:251574
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:4784
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
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