dhx34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhx34provided by ZNC
Official Full Name: DEAH (Asp-Glu-Ala-His) box polypeptide 34provided by ZNC
Primary source: ZFIN:ZDB-GENE-061207-30
See related: Ensembl:ENSDARG00000061168 AllianceGenome:ZFIN:ZDB-GENE-061207-30
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-255l12.1
Summary: Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and nuclear-transcribed mRNA catabolic process. Acts upstream of or within chordate embryonic development and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (44567191..44590092)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (44573737..44596638)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DHX34 and NBAS act in concert with core nonsense-mediated mRNA decay factors to co-regulate a large number of endogenous RNA targets.
Title: DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.
Dhx34 is required for degradation of premature termination codons-containing mRNAs in zebrafish embryos.
Title: Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DHX34

NP_001121805.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128333.1 → NP_001121805.1 probable ATP-dependent RNA helicase DHX34

Status: PROVISIONAL

Source sequence(s)

BX908775

UniProtKB/TrEMBL

A0A8M1NHU4, A0A8M6Z2K3, A2BIE5

Related

ENSDARP00000081377.5, ENSDART00000086943.6

Conserved Domains (5) summary

smart00490
Location:410 → 496

HELICc; helicase superfamily c-terminal domain

smart00847
Location:565 → 646

HA2; Helicase associated domain (HA2) Add an annotation

COG1643
Location:109 → 722

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd00046
Location:180 → 314

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:814 → 912

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold