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    larp7 La ribonucleoprotein 7, transcriptional regulator [ Danio rerio (zebrafish) ]

    Gene ID: 334956, updated on 4-Jan-2025

    Summary

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    Official Symbol
    larp7provided by ZNC
    Official Full Name
    La ribonucleoprotein 7, transcriptional regulatorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6896
    See related
    Ensembl:ENSDARG00000017315 AllianceGenome:ZFIN:ZDB-GENE-030131-6896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa10g04; zgc:56476; wu:fa10g04
    Summary
    Predicted to enable 7SK snRNA binding activity and U6 snRNA binding activity. Acts upstream of or within cardiac muscle tissue regeneration and regulation of cardiac muscle cell proliferation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in blastoderm cell and brain. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See larp7 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (59575819..59589622, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (59270509..59284422, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene SLX1 homolog B, structure-specific endonuclease subunit Neighboring gene zgc:112271 Neighboring gene ribosomal protein L34 Neighboring gene tRNA methyltransferase 44 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart. Matrone G, et al. J Cell Sci, 2015 Dec 15. PMID 26542022, Free PMC Article
    2. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Barboric M, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416841, Free PMC Article
    3. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The balance of Cdk9 and Larp7 plays a key role in cardiomyocyte proliferation and response to injury
      Title: CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U6 2'-O-snRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in box C/D sno(s)RNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cardiac muscle tissue regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of cardiac muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 7
    Names
    HDCMA18P protein
    La ribonucleoprotein domain family, member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199930.2 → NP_956224.1  la-related protein 7

      See identical proteins and their annotated locations for NP_956224.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049455
      UniProtKB/Swiss-Prot
      Q7ZWE3
      Related
      ENSDARP00000013520.4, ENSDART00000008554.5
      Conserved Domains (3) summary
      cd12290
      Location:134 → 212
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:429 → 527
      RRM_3; RNA binding motif
      cl02755
      Location:38 → 119
      LAM; LA motif RNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      59575819..59589622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166534.5 → XP_005166591.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BE41, E7F7F2
      Related
      ENSDARP00000092507.3, ENSDART00000101731.5
      Conserved Domains (3) summary
      cd08032
      Location:38 → 119
      LARP_7; La RNA-binding domain of La-related protein 7
      cd12290
      Location:134 → 212
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:429 → 527
      RRM_3; RNA binding motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZWE3.1 GenPept UniProtKB/Swiss-Prot:Q7ZWE3

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