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    slc4a4b solute carrier family 4 member 4b [ Danio rerio (zebrafish) ]

    Gene ID: 561618, updated on 4-Jan-2025

    Summary

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    Official Symbol
    slc4a4bprovided by ZNC
    Official Full Name
    solute carrier family 4 member 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091030-1
    See related
    Ensembl:ENSDARG00000044808 AllianceGenome:ZFIN:ZDB-GENE-091030-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nbc1; nbce1
    Summary
    Predicted to enable monoatomic anion transmembrane transporter activity and solute:inorganic anion antiporter activity. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in lateral plasma membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See slc4a4b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (5993187..6107536)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (5887482..6002028)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 1Bb Neighboring gene deoxycytidine kinase Neighboring gene folylpolyglutamate synthase Neighboring gene cyclin-dependent kinase 9 (CDC2-related kinase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Wang YF, et al. Proc Biol Sci, 2016 Jun 15. PMID 27306053, Free PMC Article
    2. Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. Lee YC, et al. Am J Physiol Cell Physiol, 2011 Feb. PMID 21123736
    3. Gene expression of Na+/H+ exchanger in zebrafish H+ -ATPase-rich cells during acclimation to low-Na+ and acidic environments. Yan JJ, et al. Am J Physiol Cell Physiol, 2007 Dec. PMID 17913841
    4. Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H(+)-ATPase Rich Ionocytes. Tong SK, et al. Int J Mol Sci, 2020 May 31. PMID 32486459, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    electrogenic sodium bicarbonate cotransporter 1
    Names
    sodium bicarbonate cotransporter
    solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
    solute carrier family 4, member 4
    solute carrier family 4, sodium bicarbonate cotransporter, member 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      5993187..6107536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295136.4 → XP_009293411.1  electrogenic sodium bicarbonate cotransporter 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B4G9, A0A8M9Q313
      Conserved Domains (3) summary
      TIGR00834
      Location:112 → 1033
      ae; anion exchange protein
      pfam00955
      Location:472 → 986
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:140 → 422
      Band_3_cyto; Band 3 cytoplasmic domain

    2. XM_009295135.4 → XP_009293410.1  electrogenic sodium bicarbonate cotransporter 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AL80
      Conserved Domains (3) summary
      TIGR00834
      Location:112 → 1033
      ae; anion exchange protein
      pfam00955
      Location:472 → 986
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:140 → 422
      Band_3_cyto; Band 3 cytoplasmic domain

    3. XM_685028.10 → XP_690120.7  electrogenic sodium bicarbonate cotransporter 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q313, A0A8N7UV75
      Related
      ENSDARP00000138946.2, ENSDART00000169613.3
      Conserved Domains (3) summary
      TIGR00834
      Location:112 → 1001
      ae; anion exchange protein
      pfam00955
      Location:440 → 954
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:140 → 390
      Band_3_cyto; Band 3 cytoplasmic domain

    4. XM_005160996.5 → XP_005161053.2  electrogenic sodium bicarbonate cotransporter 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B7X0, F1QD14
      Related
      ENSDARP00000048398.7, ENSDART00000048399.8
      Conserved Domains (3) summary
      TIGR00834
      Location:112 → 1001
      ae; anion exchange protein
      pfam00955
      Location:440 → 954
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:140 → 390
      Band_3_cyto; Band 3 cytoplasmic domain

    5. XM_068215971.1 → XP_068072072.1  electrogenic sodium bicarbonate cotransporter 1 isoform X5

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395078.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1211..55117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218953.1 → XP_068075054.1  electrogenic sodium bicarbonate cotransporter 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q313
    Nucleotide Protein
    Heading Accession and Version

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