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    mapk7 mitogen-activated protein kinase 7 [ Danio rerio (zebrafish) ]

    Gene ID: 541323, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mapk7provided by ZNC
    Official Full Name
    mitogen-activated protein kinase 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-10
    See related
    Ensembl:ENSDARG00000023110 AllianceGenome:ZFIN:ZDB-GENE-050320-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bmk1; erk5; fb73b02; wu:fb73b02; zgc:113111
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cell-cell junction maintenance; digestive tract development; and ossification. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; gut; head; pronephric duct; and tail bud. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mapk7 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4222854..4238827)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4186094..4202062)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene dendrite extension defective protein 1-like Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene zgc:92313 Neighboring gene matrix metallopeptidase 25b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis. Gao W, et al. Hum Mutat, 2017 Nov. PMID 28714182
    2. Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Zhou T, et al. Cell Physiol Biochem, 2018. PMID 30032135
    3. Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling. Xie X, et al. Curr Mol Med, 2018. PMID 29577856
    4. The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases. Wu N, et al. Comput Struct Biotechnol J, 2019. PMID 31360334, Free PMC Article
    5. Erk5 functions in modulation of zebrafish intestinal permeability. Lv H, et al. Cell Tissue Res, 2023 Aug. PMID 37256363

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Erk5 functions in modulation of zebrafish intestinal permeability.
      Title: Erk5 functions in modulation of zebrafish intestinal permeability.
    2. The data suggest that flow-induced ERK5-klf2a-nos2b signaling is involved in CVP angiogenesis in zebrafish embryos.
      Title: Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-cell junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ossification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 7
    Names
    extracellular signal-regulated kinase 5
    NP_001013469.2
    XP_005156059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013451.3 → NP_001013469.2  mitogen-activated protein kinase 7

      See identical proteins and their annotated locations for NP_001013469.2

      Status: VALIDATED

      Source sequence(s)
      AL954132, DQ360072
      UniProtKB/TrEMBL
      A0A8M1N4F1, Q0H1F4
      Related
      ENSDARP00000042276.5, ENSDART00000042277.7
      Conserved Domains (2) summary
      smart00220
      Location:80 → 373
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:74 → 410
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      4222854..4238827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156002.5 → XP_005156059.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B237, E9QEY0
      Related
      ENSDARP00000119429.1, ENSDART00000133675.4
      Conserved Domains (2) summary
      smart00220
      Location:80 → 373
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:74 → 410
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    Nucleotide Protein
    Heading Accession and Version

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