CYREN cell cycle regulator of NHEJ [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYRENprovided by HGNC
Official Full Name: cell cycle regulator of NHEJprovided by HGNC
Primary source: HGNC:HGNC:22432
See related: Ensembl:ENSG00000122783 MIM:616980; AllianceGenome:HGNC:22432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRI; MRI-2; C7orf49; CYREN-1; CYREN-2
Summary: Predicted to enable damaged DNA binding activity. Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung (RPKM 6.0), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (135092303..135172469, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (136400107..136478562, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (134777061..134855459, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

proposition that CYREN is a direct cell-cycle-dependent inhibitor of cNHEJ that promotes error-free repair by homologous recombination during cell cycle phases when sister chromatids are present
Title: Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.
Interacts with Ku and enhances efficiency of DNA double strand break ligation in vitro
Title: A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.
Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection.
Title: Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80739 (e-PCR)
- UniSTS:89647

D7S2063E (e-PCR)
- UniSTS:151118

RH102155 (e-PCR)
- UniSTS:96489

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via nonhomologous end joining	IDA Inferred from Direct Assay more info	PubMed
involved_in immunoglobulin V(D)J recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
involved_in protein localization to site of double-strand break	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA repair complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cell cycle regulator of non-homologous end joining

Names: modulator of retrovirus infection homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243749.2 → NP_001230678.1 cell cycle regulator of non-homologous end joining isoform 2

See identical proteins and their annotated locations for NP_001230678.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK026103, BC000168, CB961457

Consensus CDS

CCDS75663.1

UniProtKB/TrEMBL

C9JKC7
NM_001243751.2 → NP_001230680.1 cell cycle regulator of non-homologous end joining isoform 2

See identical proteins and their annotated locations for NP_001230680.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC000168, BC067350, CB961457

Consensus CDS

CCDS75663.1

UniProtKB/TrEMBL

C9JKC7

Related

ENSP00000389941.2, ENST00000430372.1
NM_001243752.2 → NP_001230681.1 cell cycle regulator of non-homologous end joining isoform 2

See identical proteins and their annotated locations for NP_001230681.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC083862, AI632984, BC000168, BE674385, BM727569, DA213716

Consensus CDS

CCDS75663.1

UniProtKB/TrEMBL

C9JKC7

Related

ENSP00000480430.1, ENST00000617987.1
NM_001243753.2 → NP_001230682.1 cell cycle regulator of non-homologous end joining isoform 2

See identical proteins and their annotated locations for NP_001230682.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC083862, BC000168, BG770658

Consensus CDS

CCDS75663.1

UniProtKB/TrEMBL

C9JKC7
NM_001243754.2 → NP_001230683.1 cell cycle regulator of non-homologous end joining isoform 3

See identical proteins and their annotated locations for NP_001230683.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC000168, BQ423284

Consensus CDS

CCDS59082.1

UniProtKB/Swiss-Prot

Q9BWK5

Related

ENSP00000473365.1, ENST00000483029.2

Conserved Domains (1) summary

pfam15325
Location:1 → 102

MRI; Modulator of retrovirus infection
NM_001243755.2 → NP_001230684.1 cell cycle regulator of non-homologous end joining isoform 3

See identical proteins and their annotated locations for NP_001230684.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC083862, AL708733, BC000168

Consensus CDS

CCDS59082.1

UniProtKB/Swiss-Prot

Q9BWK5

Related

ENSP00000481014.1, ENST00000620897.4

Conserved Domains (1) summary

pfam15325
Location:1 → 102

MRI; Modulator of retrovirus infection
NM_001305629.2 → NP_001292558.1 cell cycle regulator of non-homologous end joining isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (8) uses an alternate splice site and lacks an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC083862, BC067350, HY026093

UniProtKB/Swiss-Prot

Q9BWK5

Conserved Domains (1) summary

pfam15325
Location:59 → 144

MRI; Modulator of retrovirus infection
NM_001305630.2 → NP_001292559.1 cell cycle regulator of non-homologous end joining isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (9) uses an alternate splice site, lacks a portion of the 3' coding region, and contains an alternate 3' terminal exon, resulting in a distinct 3' UTR, compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus than isoform 1.

Source sequence(s)

AC083862, AI335567, BC050676, CB961457

UniProtKB/TrEMBL

C9JKC7

Related

ENST00000459937.5
NM_001363329.2 → NP_001350258.1 cell cycle regulator of non-homologous end joining isoform 1

Status: VALIDATED

Source sequence(s)

BC000168, BP213903, CB132932

Consensus CDS

CCDS5838.2

UniProtKB/Swiss-Prot

A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5

Conserved Domains (1) summary

pfam15325
Location:52 → 157

MRI; Modulator of retrovirus infection
NM_001363330.2 → NP_001350259.1 cell cycle regulator of non-homologous end joining isoform 1

Status: VALIDATED

Source sequence(s)

AC083862, BC000168, BE674385, BP213903, CB132932

Consensus CDS

CCDS5838.2

UniProtKB/Swiss-Prot

A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5

Conserved Domains (1) summary

pfam15325
Location:52 → 157

MRI; Modulator of retrovirus infection
NM_024033.4 → NP_076938.2 cell cycle regulator of non-homologous end joining isoform 1

See identical proteins and their annotated locations for NP_076938.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1, also known as MRI-1).

Source sequence(s)

AC083862

Consensus CDS

CCDS5838.2

UniProtKB/Swiss-Prot

A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5

Related

ENSP00000376823.3, ENST00000393114.8

Conserved Domains (1) summary

pfam15325
Location:52 → 157

MRI; Modulator of retrovirus infection

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

135092303..135172469 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017012595.2 → XP_016868084.1 cell cycle regulator of non-homologous end joining isoform X2

UniProtKB/TrEMBL

C9JKC7
XM_017012591.3 → XP_016868080.1 cell cycle regulator of non-homologous end joining isoform X3

UniProtKB/Swiss-Prot

A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5

Conserved Domains (1) summary

pfam15325
Location:52 → 157

MRI; Modulator of retrovirus infection
XM_047420824.1 → XP_047276780.1 cell cycle regulator of non-homologous end joining isoform X1
XM_017012592.3 → XP_016868081.1 cell cycle regulator of non-homologous end joining isoform X1

Conserved Domains (1) summary

pfam15325
Location:59 → 144

MRI; Modulator of retrovirus infection
XM_047420823.1 → XP_047276779.1 cell cycle regulator of non-homologous end joining isoform X1
XM_047420825.1 → XP_047276781.1 cell cycle regulator of non-homologous end joining isoform X2

UniProtKB/TrEMBL

C9JKC7
XM_047420826.1 → XP_047276782.1 cell cycle regulator of non-homologous end joining isoform X2

UniProtKB/TrEMBL

C9JKC7

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

136400107..136478562 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358988.1 → XP_054214963.1 cell cycle regulator of non-homologous end joining isoform X2

UniProtKB/TrEMBL

C9JKC7
XM_054358984.1 → XP_054214959.1 cell cycle regulator of non-homologous end joining isoform X1
XM_054358985.1 → XP_054214960.1 cell cycle regulator of non-homologous end joining isoform X1
XM_054358986.1 → XP_054214961.1 cell cycle regulator of non-homologous end joining isoform X2

UniProtKB/TrEMBL

C9JKC7
XM_054358987.1 → XP_054214962.1 cell cycle regulator of non-homologous end joining isoform X2

UniProtKB/TrEMBL

C9JKC7