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    Prmt1 protein arginine N-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15469, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prmt1provided by MGI
    Official Full Name
    protein arginine N-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:107846
    See related
    Ensembl:ENSMUSG00000109324 AllianceGenome:MGI:107846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrmt1; Hrmt1l2; 6720434D09Rik
    Summary
    Enables GATOR1 complex binding activity; histone methyltransferase activity; and protein-arginine omega-N asymmetric methyltransferase activity. Involved in several processes, including RNA splicing; cellular response to methionine; and positive regulation of TORC1 signaling. Acts upstream of or within in utero embryonic development. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and lung. Used to study cleft palate. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prmt1 in Genome Data Viewer
    Location:
    7 B3; 7 29.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44626179..44635844, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44976755..44986420, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene predicted gene 15545 Neighboring gene BCL2 like 12 Neighboring gene interferon regulatory factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GATOR1 complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables S-adenosyl-L-methionine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AQ104 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K37 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R17 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R26 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R8 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K12 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4R3 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4R3 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mitogen-activated protein kinase p38 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase p38 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine omega-N monomethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-arginine omega-N monomethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine omega-N monomethyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables snoRNP binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to methionine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to methionine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-arginine omega-N-methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methylosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 1
    Names
    arginine N-methyltransferase 1
    heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
    histone-arginine N-methyltransferase PRMT1
    NP_001239405.1
    NP_001239406.1
    NP_062804.1
    XP_030098017.1
    XP_030098018.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252476.1NP_001239405.1  protein arginine N-methyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001239405.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AI846916, AK152342, BU524421, BY760714
      Consensus CDS
      CCDS57547.1
      UniProtKB/TrEMBL
      F8WH01, Q3UIG8, Q80WB1
      Related
      ENSMUSP00000147252.2, ENSMUST00000207370.2
      Conserved Domains (1) summary
      cd02440
      Location:74174
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001252477.1NP_001239406.1  protein arginine N-methyltransferase 1 isoform 3

      See identical proteins and their annotated locations for NP_001239406.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AI846916, AK020120, BU524421, W49313
      Consensus CDS
      CCDS85293.1
      UniProtKB/TrEMBL
      A0A140LJ70, Q9CX58
      Related
      ENSMUSP00000147101.2, ENSMUST00000207659.2
      Conserved Domains (1) summary
      cd02440
      Location:74140
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_019830.3NP_062804.1  protein arginine N-methyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_062804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AF232716, AI846916, BU524421, BY760714
      Consensus CDS
      CCDS21222.1
      UniProtKB/Swiss-Prot
      Q99LS4, Q9JIF0
      UniProtKB/TrEMBL
      Q8C2D7
      Related
      ENSMUSP00000103474.4, ENSMUST00000107843.11
      Conserved Domains (1) summary
      cd02440
      Location:92192
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_045521.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI846916, BC051953, BU524421

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44626179..44635844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242158.2XP_030098018.1  protein arginine N-methyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      Q8C2D7
      Conserved Domains (1) summary
      cd02440
      Location:63163
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_030242157.2XP_030098017.1  protein arginine N-methyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q80WV6, Q8C2D7
      Conserved Domains (1) summary
      cd02440
      Location:75175
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...