PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PHLPP2provided by HGNC
Official Full Name: PH domain and leucine rich repeat protein phosphatase 2provided by HGNC
Primary source: HGNC:HGNC:29149
See related: Ensembl:ENSG00000040199 MIM:611066; AllianceGenome:HGNC:29149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PPM3B; PHLPPL
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q22.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (71644924..71724701, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (77462088..77541847, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (71678827..71758604, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers.
Title: PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers.
Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma.
Title: Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma.
TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.
Title: TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.
PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble.
Title: PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble.
MARCH1 silencing suppresses growth of oral squamous cell carcinoma through regulation of PHLPP2.
Title: MARCH1 silencing suppresses growth of oral squamous cell carcinoma through regulation of PHLPP2.
Integrated Analysis of Ulcerative Colitis Revealed an Association between PHLPP2 and Immune Infiltration.
Title: Integrated Analysis of Ulcerative Colitis Revealed an Association between PHLPP2 and Immune Infiltration.
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.
Title: Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.
TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells.
Title: TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells.
MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer.
Title: MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer.
Circular RNA circ_0001017 Sensitizes Cisplatin-Resistant Gastric Cancer Cells to Chemotherapy by the miR-543/PHLPP2 Axis.
Title: Circular RNA circ_0001017 Sensitizes Cisplatin-Resistant Gastric Cancer Cells to Chemotherapy by the miR-543/PHLPP2 Axis.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH80500 (e-PCR)
- UniSTS:91701

D16S2624 (e-PCR), detects polymorphism
- UniSTS:70490

D16S751 (e-PCR)
- UniSTS:61038

RH15650 (e-PCR)
- UniSTS:6283

PMC164657P2 (e-PCR)
- UniSTS:271509

WI-21728 (e-PCR)
- UniSTS:66470

D16S485 (e-PCR)
- UniSTS:69300

GDB:631813 (e-PCR)
- UniSTS:158430

RH80031 (e-PCR)
- UniSTS:91103

SHGC-64276 (e-PCR)
- UniSTS:70141

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PH domain leucine-rich repeat-containing protein phosphatase 2

Names: protein phosphatase, Mg2+/Mn2+ dependent 3B

NP_001275932.1

EC 3.1.3.16

NP_055835.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289003.1 → NP_001275932.1 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 2

See identical proteins and their annotated locations for NP_001275932.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AB023148, AC009097, BC129927

Consensus CDS

CCDS73910.1

UniProtKB/TrEMBL

H3BMS5

Related

ENSP00000377159.2, ENST00000393524.6

Conserved Domains (5) summary

cd00116
Location:444 → 660

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00143
Location:717 → 966

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cd13322
Location:149 → 243

PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain

sd00033
Location:442 → 461

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:572 → 636

LRR_8; Leucine rich repeat
NM_015020.3 → NP_055835.2 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1

See identical proteins and their annotated locations for NP_055835.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC009097, BC129927, BX647823

Consensus CDS

CCDS32479.1

UniProtKB/Swiss-Prot

A1L374, Q6ZVD8, Q9NV17, Q9Y2E3

UniProtKB/TrEMBL

H3BMS5

Related

ENSP00000457991.1, ENST00000568954.5

Conserved Domains (6) summary

cd00116
Location:313 → 606

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00143
Location:784 → 1033

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

cd13322
Location:149 → 243

PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain

sd00033
Location:482 → 503

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:645 → 685

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:645 → 703

LRR_8; Leucine rich repeat