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    Hspa2 heat shock protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 15512, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hspa2provided by MGI
    Official Full Name
    heat shock protein 2provided by MGI
    Primary source
    MGI:MGI:96243
    See related
    Ensembl:ENSMUSG00000059970 AllianceGenome:MGI:96243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa; HSP70.2; HSP70A2; Hsp70-2
    Summary
    Enables glycolipid binding activity. Involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity and spermatogenesis. Acts upstream of or within several processes, including male meiosis I; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Located in cell surface; meiotic spindle; and nucleus. Part of CatSper complex. Is expressed in several structures, including 2-cell stage embryo; alimentary system; ganglia; medulla oblongata basal plate; and submandibular gland primordium. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 333.5), bladder adult (RPKM 20.6) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hspa2 in Genome Data Viewer
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76450688..76453712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76403812..76406938)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 5 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene STARR-seq mESC enhancer starr_32516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468237-77468545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468685-77468794 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene STARR-positive B cell enhancer ABC_E94 Neighboring gene STARR-seq mESC enhancer starr_32522 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene, 25563 Neighboring gene Ppp1r36 downstream neighbor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC7795, MGC58299

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables disordered domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inclusion body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptonemal complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock-related 70 kDa protein 2
    Names
    heat shock 70kDa protein 2
    heat shock protein 70.2
    heat shock protein, 70 kDa 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002012.2NP_001002012.1  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_001002012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      BC052350
      Consensus CDS
      CCDS25993.1
      UniProtKB/Swiss-Prot
      P17156, Q99KD7
      UniProtKB/TrEMBL
      B7U582
      Related
      ENSMUSP00000079306.6, ENSMUST00000080449.7
      Conserved Domains (1) summary
      PTZ00009
      Location:2615
      PTZ00009; heat shock 70 kDa protein; Provisional
    2. NM_001409571.1NP_001396500.1  heat shock-related 70 kDa protein 2

      Status: VALIDATED

      Source sequence(s)
      AC124453
      UniProtKB/Swiss-Prot
      P17156, Q99KD7
      UniProtKB/TrEMBL
      B7U582
    3. NM_001409572.1NP_001396501.1  heat shock-related 70 kDa protein 2

      Status: VALIDATED

      Source sequence(s)
      AC124453
      UniProtKB/Swiss-Prot
      P17156, Q99KD7
      UniProtKB/TrEMBL
      B7U582
    4. NM_008301.5NP_032327.2  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_032327.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AK132261, BC052350
      Consensus CDS
      CCDS25993.1
      UniProtKB/Swiss-Prot
      P17156, Q99KD7
      UniProtKB/TrEMBL
      B7U582
      Related
      ENSMUSP00000151408.2, ENSMUST00000219555.2
      Conserved Domains (1) summary
      PTZ00009
      Location:2615
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      76450688..76453712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)