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    Rab15 RAB15, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 104886, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rab15provided by MGI
    Official Full Name
    RAB15, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1916865
    See related
    Ensembl:ENSMUSG00000021062 AllianceGenome:MGI:1916865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310012G06Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in exocytosis and positive regulation of regulated secretory pathway. Predicted to be located in cilium and perinuclear region of cytoplasm. Predicted to be active in endosome membrane. Is expressed in several structures, including 1st branchial arch; central nervous system; embryo endoderm; inner ear; and vibrissa. Orthologous to human RAB15 (RAB15, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 9.0), cortex adult (RPKM 7.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Rab15 in Genome Data Viewer
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76844734..76869532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76797960..76822759, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32533 Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2 Neighboring gene STARR-seq mESC enhancer starr_32534 Neighboring gene predicted gene, 34988 Neighboring gene STARR-positive B cell enhancer ABC_E2389 Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene predicted gene, 46357 Neighboring gene predicted gene, 46358 Neighboring gene STARR-seq mESC enhancer starr_32542

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347405.1NP_001334334.1  ras-related protein Rab-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132331, AI840042, AK158637, AK158768
      Consensus CDS
      CCDS83970.1
      UniProtKB/TrEMBL
      D3YTZ8, D3YWS1
      Related
      ENSMUSP00000113299.2, ENSMUST00000121716.8
      Conserved Domains (1) summary
      cl38936
      Location:1126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001347406.1NP_001334335.1  ras-related protein Rab-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132331, AI840042, AK158637, AK158768
      Consensus CDS
      CCDS83970.1
      UniProtKB/TrEMBL
      D3YTZ8, D3YWS1
      Related
      ENSMUSP00000112789.2, ENSMUST00000118604.8
      Conserved Domains (1) summary
      cl38936
      Location:1126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_001347407.1NP_001334336.1  ras-related protein Rab-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI840042, AK158637, AK158768, BY239543
      Consensus CDS
      CCDS83970.1
      UniProtKB/TrEMBL
      D3YTZ8, D3YWS1
      Conserved Domains (1) summary
      cl38936
      Location:1126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. NM_134050.5NP_598811.3  ras-related protein Rab-15 isoform 1

      See identical proteins and their annotated locations for NP_598811.3

      Status: VALIDATED

      Source sequence(s)
      AI840042, AK158637, AK158768, BY237353
      Consensus CDS
      CCDS25997.1
      UniProtKB/Swiss-Prot
      Q8K386
      UniProtKB/TrEMBL
      Q0PD40, Q3TYH2
      Related
      ENSMUSP00000021459.8, ENSMUST00000021459.14
      Conserved Domains (1) summary
      cd04117
      Location:9172
      Rab15; Rab GTPase family 15 (Rab15)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      76844734..76869532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_381469.5 RNA Sequence