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    Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) [ Mus musculus (house mouse) ]

    Gene ID: 17135, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mafkprovided by MGI
    Official Full Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)provided by MGI
    Primary source
    MGI:MGI:99951
    See related
    Ensembl:ENSMUSG00000018143 AllianceGenome:MGI:99951
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NF-E2; Nfe2u
    Summary
    Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and immune system. Orthologous to human MAFK (MAF bZIP transcription factor K). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 16.9), colon adult (RPKM 16.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mafk in Genome Data Viewer
    Location:
    5 G2; 5 78.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139777291..139788409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139791536..139802653)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene MICAL-like 2 Neighboring gene STARR-seq mESC enhancer starr_14697 Neighboring gene STARR-positive B cell enhancer ABC_E8087 Neighboring gene integrator complex subunit 1 Neighboring gene microRNA 7037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140252978-140253165 Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene transmembrane protein 184a Neighboring gene proteasome (prosome, macropain) assembly chaperone 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor MafK
    Names
    erythroid transcription factor NF-E2 p18 subunit
    nuclear factor, erythroid derived 2, ubiquitous
    p18 NF-E2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010757.2NP_034887.1  transcription factor MafK

      See identical proteins and their annotated locations for NP_034887.1

      Status: PROVISIONAL

      Source sequence(s)
      AC167333
      Consensus CDS
      CCDS19814.1
      UniProtKB/Swiss-Prot
      Q60600, Q61827
      UniProtKB/TrEMBL
      Q3U568, Q3UP84
      Related
      ENSMUSP00000018287.4, ENSMUST00000018287.10
      Conserved Domains (1) summary
      cd14717
      Location:46115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139777291..139788409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504653.5XP_006504716.1  transcription factor MafK isoform X1

      See identical proteins and their annotated locations for XP_006504716.1

      UniProtKB/Swiss-Prot
      Q60600, Q61827
      UniProtKB/TrEMBL
      Q3U568, Q3UP84
      Related
      ENSMUSP00000106460.2, ENSMUST00000110836.2
      Conserved Domains (1) summary
      cd14717
      Location:46115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain