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    Max Max protein [ Mus musculus (house mouse) ]

    Gene ID: 17187, updated on 9-Dec-2024

    Summary

    Official Symbol
    Maxprovided by MGI
    Official Full Name
    Max proteinprovided by MGI
    Primary source
    MGI:MGI:96921
    See related
    Ensembl:ENSMUSG00000059436 AllianceGenome:MGI:96921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Part of Myc-Max complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lens; and upper jaw. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 24.2), small intestine adult (RPKM 21.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Max in Genome Data Viewer
    Location:
    12 C3; 12 33.78 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76984045..77009123, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76937269..76962323, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene predicted gene, 46357 Neighboring gene predicted gene, 46358 Neighboring gene STARR-seq mESC enhancer starr_32542 Neighboring gene STARR-positive B cell enhancer ABC_E3056 Neighboring gene STARR-seq mESC enhancer starr_32548 Neighboring gene predicted gene, 35041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:78140672-78140781 Neighboring gene predicted gene, 35189

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables E-box binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Mad-Max complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Myc-Max complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of Myc-Max complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein max
    Names
    myc-associated factor X
    myc-binding novel HLH/LZ protein
    protein myn

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146176.2NP_001139648.1  protein max isoform 2

      See identical proteins and their annotated locations for NP_001139648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1 but maintains the reading frame. The encoded protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC124556
      Consensus CDS
      CCDS49094.1
      UniProtKB/TrEMBL
      Q8C4Y1
      Related
      ENSMUSP00000080778.6, ENSMUST00000082136.7
      Conserved Domains (1) summary
      cd11406
      Location:1583
      bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins
    2. NM_001361663.2NP_001348592.1  protein max isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124556
      Conserved Domains (1) summary
      cd11406
      Location:2492
      bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins
    3. NM_001361664.2NP_001348593.1  protein max isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124556
    4. NM_001422052.1NP_001408981.1  protein max isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124556
      UniProtKB/TrEMBL
      A0A1W2P7P4
      Related
      ENSMUSP00000151710.2, ENSMUST00000218640.2
    5. NM_001422053.1NP_001408982.1  protein max isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124556
    6. NM_008558.3NP_032584.2  protein max isoform 1

      See identical proteins and their annotated locations for NP_032584.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC124556
      Consensus CDS
      CCDS36479.1
      UniProtKB/Swiss-Prot
      B2RS19, P28574, Q8C4Y1
      Related
      ENSMUSP00000106025.4, ENSMUST00000110395.11
      Conserved Domains (1) summary
      cd11406
      Location:2492
      bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins

    RNA

    1. NR_185481.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124556

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      76984045..77009123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157209.1XP_036013102.1  protein max isoform X2

    2. XM_030246570.2XP_030102430.1  protein max isoform X2

    3. XM_030246571.1XP_030102431.1  protein max isoform X2

    RNA

    1. XR_872708.4 RNA Sequence