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    Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 16848, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lfngprovided by MGI
    Official Full Name
    LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1095413
    See related
    Ensembl:ENSMUSG00000029570 AllianceGenome:MGI:1095413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Acts upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 3. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 77.7), mammary gland adult (RPKM 72.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lfng in Genome Data Viewer
    Location:
    5 G2; 5 79.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140593096..140601300)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140607341..140615545)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141043369-141043556 Neighboring gene STARR-positive B cell enhancer ABC_E8088 Neighboring gene galectin-related inter-fiber protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141072932-141073102 Neighboring gene predicted gene, 30603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141093710-141094027 Neighboring gene STARR-positive B cell enhancer ABC_E11729 Neighboring gene tweety family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6392 Neighboring gene IQ motif containing E Neighboring gene STARR-positive B cell enhancer ABC_E11307

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within compartment pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in marginal zone B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Notch signaling pathway involved in somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Names
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    lunatic fringe
    NP_032520.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008494.3NP_032520.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

      See identical proteins and their annotated locations for NP_032520.1

      Status: VALIDATED

      Source sequence(s)
      AK004642, AK153283, AW061165
      Consensus CDS
      CCDS19821.1
      UniProtKB/Swiss-Prot
      O09010, Q3U659, Q8K3F1, Q9DC10
      UniProtKB/TrEMBL
      B2RRW2
      Related
      ENSMUSP00000031555.2, ENSMUST00000031555.3
      Conserved Domains (1) summary
      pfam02434
      Location:109357
      Fringe; Fringe-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140593096..140601300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)