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    Zfy1 zinc finger protein 1, Y-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 103694540, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfy1provided by RGD
    Official Full Name
    zinc finger protein 1, Y-linkedprovided by RGD
    Primary source
    RGD:9203794
    See related
    EnsemblRapid:ENSRNOG00000053042 AllianceGenome:RGD:9203794
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ZFY
    Summary
    Predicted to enable chromatin insulator sequence binding activity and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in chromosome. Orthologous to several human genes including ZFY (zinc finger protein Y-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 20.8), Spleen (RPKM 2.3) and 7 other tissues See more
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    Genomic context

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    See Zfy1 in Genome Data Viewer
    Location:
    Yq11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) Y NC_086040.1 (146762..188124, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) Y Unlocalized Scaffold NW_023637718.1 (232362..272469)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) Y NC_024475.1 (182497..222212)

    Chromosome Y - NC_086040.1Genomic Context describing neighboring genes Neighboring gene LIM domain-containing protein 2 pseudogene Neighboring gene uncharacterized LOC108353310 Neighboring gene UPF0547 protein C16orf87 homolog pseudogene Neighboring gene testis specific protein, Y-linked 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus. Yu M, et al. Cancer Epidemiol Biomarkers Prev, 2015 Dec. PMID 26545406, Free PMC Article
    2. Origins and functional evolution of Y chromosomes across mammals. Cortez D, et al. Nature, 2014 Apr 24. PMID 24759410
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger Y-chromosomal protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086040.1 Reference GRCr8

      Range
      146762..188124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100725.2 → XP_038956653.1  zinc finger Y-chromosomal protein 2

      UniProtKB/TrEMBL
      A0A0G2K3V6, A0A1B0GWY2
      Related
      ENSRNOP00000072793.1, ENSRNOT00000077708.3
      Conserved Domains (5) summary
      COG5048
      Location:508 → 694
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:695 → 717
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:68 → 388
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:538 → 562
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039100724.2 → XP_038956652.1  zinc finger Y-chromosomal protein 2

      UniProtKB/TrEMBL
      A0A0G2K3V6, A0A1B0GWY2
      Conserved Domains (5) summary
      COG5048
      Location:508 → 694
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:695 → 717
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:68 → 388
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:538 → 562
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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