Endod1 endonuclease domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Endod1provided by MGI
Official Full Name: endonuclease domain containing 1provided by MGI
Primary source: MGI:MGI:1919196
See related: Ensembl:ENSMUSG00000037419 AllianceGenome:MGI:1919196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210414F18Rik; 2310067E08Rik
Summary: Predicted to enable endonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in innate immune response. Predicted to be located in extracellular region. Is expressed in several structures, including brain; dorsal root ganglion; liver; neural retina; and olfactory epithelium. Orthologous to human ENDOD1 (endonuclease domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in colon adult (RPKM 61.0), cerebellum adult (RPKM 29.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 3.96 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (14265286..14292538, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (14353990..14381242, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synthetic lethality between TP53 and ENDOD1.
Title: Synthetic lethality between TP53 and ENDOD1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236057

C85344 (e-PCR)
- UniSTS:159853

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endonuclease domain-containing 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028013.3 → NP_082289.2 endonuclease domain-containing 1 protein precursor

Status: VALIDATED

Source sequence(s)

AK173036, BY483505

Consensus CDS

CCDS22821.1

UniProtKB/Swiss-Prot

Q4VA96, Q8C522, Q8C5M1, Q8VE35

UniProtKB/TrEMBL

Q69ZY2

Related

ENSMUSP00000127751.2, ENSMUST00000167549.2

Conserved Domains (1) summary

cd00091
Location:65 → 281

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

14265286..14292538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313601.2 → XP_017169090.1 endonuclease domain-containing 1 protein isoform X1

UniProtKB/TrEMBL

Q3UQH3

Conserved Domains (2) summary

pfam15070
Location:123 → 172

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

cl00089
Location:1 → 127

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.