Impdh2 inosine monophosphate dehydrogenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Impdh2provided by MGI
Official Full Name: inosine monophosphate dehydrogenase 2provided by MGI
Primary source: MGI:MGI:109367
See related: Ensembl:ENSMUSG00000062867 AllianceGenome:MGI:109367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMPD; IMPD 2; IMPDH-II
Summary: Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within cellular response to interleukin-4; lymphocyte proliferation; and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; heart; respiratory system; and sensory organ. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 65.1), liver E14.5 (RPKM 58.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.5 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108437635..108442776)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108560436..108565577)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impdh2 deficiency suppresses osteoclastogenesis through mitochondrial oxidative phosphorylation and alleviates ovariectomy-induced osteoporosis.
Title: Impdh2 deficiency suppresses osteoclastogenesis through mitochondrial oxidative phosphorylation and alleviates ovariectomy-induced osteoporosis.
Deletion of Impdh2 in adipocyte precursors limits the expansion of white adipose tissue and enhances metabolic health with overnutrition.
Title: Deletion of Impdh2 in adipocyte precursors limits the expansion of white adipose tissue and enhances metabolic health with overnutrition.
The IMPDH cytoophidium couples metabolism and fetal development in mice.
Title: The IMPDH cytoophidium couples metabolism and fetal development in mice.
IMPDH2 forms spots at branching sites and distal ends of astrocyte stem processes.
Title: IMPDH2 forms spots at branching sites and distal ends of astrocyte stem processes.
TCR stimulation promotes IMPDH 1 and IMPDH 2 assembly in T lymphocytes.
Title: T cell activation triggers reversible inosine-5'-monophosphate dehydrogenase assembly.
IMPDH2 mediated guanine nucleotide synthesis is essential for normal development of the enteric nervous system and other neural crest derivatives.
Title: Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.
various carbon atom lengths and double bonds of fatty acids were examined for inhibitory strength; docking simulation of C20-fatty acids and mouse IMPDH type II was performed.
Title: Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables IMP dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables IMP dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables IMP dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 'de novo' XMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GMP salvage	TAS Traceable Author Statement more info	PubMed
involved_in GTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GTP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within purine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inosine-5'-monophosphate dehydrogenase 2

Names: IMP dehydrogenase 2; IMP dehydrogenase type II; inosine 5'-phosphate dehydrogenase 2

NP_001365850.1

EC 1.1.1.205

NP_035960.2

EC 1.1.1.205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378921.1 → NP_001365850.1 inosine-5'-monophosphate dehydrogenase 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CT010508

UniProtKB/TrEMBL

Q3U9N8, Q3UPJ2

Conserved Domains (1) summary

PTZ00314
Location:16 → 534

PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
NM_011830.5 → NP_035960.2 inosine-5'-monophosphate dehydrogenase 2 isoform 2

See identical proteins and their annotated locations for NP_035960.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CT010508

Consensus CDS

CCDS40768.1

UniProtKB/Swiss-Prot

P24547, Q61734, Q91Z11

UniProtKB/TrEMBL

Q3U9N8, Q3UAT9, Q3UPJ2

Related

ENSMUSP00000079888.9, ENSMUST00000081111.14

Conserved Domains (1) summary

PTZ00314
Location:16 → 510

PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional