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    Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 [ Mus musculus (house mouse) ]

    Gene ID: 59013, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnph1provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H1provided by MGI
    Primary source
    MGI:MGI:1891925
    See related
    Ensembl:ENSMUSG00000007850 AllianceGenome:MGI:1891925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrnph; Hnrph1; E430005G16Rik
    Summary
    Predicted to enable RNA binding activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within cellular response to interleukin-7. Predicted to be located in cytosol and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm and postsynaptic density. Is expressed in several structures, including brain; gut; liver; olfactory epithelium; and respiratory system. Human ortholog(s) of this gene implicated in Sjogren's syndrome. Orthologous to human HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 294.5), CNS E14 (RPKM 202.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnrnph1 in Genome Data Viewer
    Location:
    11 B1.3; 11 30.56 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50266084..50277355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50375257..50386528)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene predicted gene, 53701 Neighboring gene STARR-positive B cell enhancer ABC_E6978 Neighboring gene microRNA 804 Neighboring gene chibby family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50190892-50191075 Neighboring gene STARR-positive B cell enhancer ABC_E2985 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2986 Neighboring gene STARR-positive B cell enhancer ABC_E5222 Neighboring gene predicted gene, 53702

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heterogeneous nuclear ribonucleoprotein-H plays a suppressive role in visceral myogenesis. Liu J, et al. Mech Dev, 2001 Jun. PMID 11404082
    2. Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice. Bryant CD, et al. Genes Brain Behav, 2021 Mar. PMID 33145940
    3. Hnrnph1 is a novel regulator of alcohol reward. Fultz EK, et al. Drug Alcohol Depend, 2021 Mar 1. PMID 33454624, Free PMC Article
    4. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice. Borrelli KN, et al. Psychopharmacology (Berl), 2021 Jul. PMID 33758972, Free PMC Article
    5. Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. Yazdani N, et al. PLoS Genet, 2015 Dec. PMID 26658939, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
      Title: A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
    2. hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
      Title: hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
    3. hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
      Title: hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
    4. Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.
      Title: Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.
    5. The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis.
      Title: The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis.
    6. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.
      Title: Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.
    7. Hnrnph1 is a novel regulator of alcohol reward.
      Title: Hnrnph1 is a novel regulator of alcohol reward.
    8. There is a role for the RNA binding protein hnRNP H in methamphetamine reward and reinforcement. Hnrnph1 mutation also blunted methamphetamine-induced dopamine release in the NAc, a key neurochemical event contributing to methamphetamine addiction liability. Finally, Hnrnph1 mutants showed a marked increase in basal level of synaptosomal hnRNP H and mitochondrial proteins that decreased in response to methamphetamine.
      Title: A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.
    9. These results define a novel contribution of Hnrnph1 to neurobehavioral dysfunction associated with dopaminergic neurotransmission.
      Title: Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity.
    10. hnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
      Title: Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347487.2 → NP_001334416.1  heterogeneous nuclear ribonucleoprotein H isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA124353, AK165283, AL645904, BY307937, BY787002, CO426010, DV657681
      Consensus CDS
      CCDS83800.1
      UniProtKB/TrEMBL
      Q8C2Q7
      Related
      ENSMUSP00000076989.8, ENSMUST00000077817.8
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    2. NM_001362522.1 → NP_001349451.1  heterogeneous nuclear ribonucleoprotein H isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    3. NM_001362523.1 → NP_001349452.1  heterogeneous nuclear ribonucleoprotein H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK161491, AL645904
      Consensus CDS
      CCDS24634.1
      UniProtKB/Swiss-Prot
      O35737
      UniProtKB/TrEMBL
      Q811L7
      Related
      ENSMUSP00000104770.2, ENSMUST00000109142.8
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    4. NM_001362524.1 → NP_001349453.1  heterogeneous nuclear ribonucleoprotein H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Consensus CDS
      CCDS24634.1
      UniProtKB/Swiss-Prot
      O35737
      UniProtKB/TrEMBL
      Q811L7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    5. NM_001362525.1 → NP_001349454.1  heterogeneous nuclear ribonucleoprotein H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Consensus CDS
      CCDS24634.1
      UniProtKB/Swiss-Prot
      O35737
      UniProtKB/TrEMBL
      Q811L7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    6. NM_001362526.1 → NP_001349455.1  heterogeneous nuclear ribonucleoprotein H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Consensus CDS
      CCDS24634.1
      UniProtKB/Swiss-Prot
      O35737
      UniProtKB/TrEMBL
      Q811L7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    7. NM_001362527.1 → NP_001349456.1  heterogeneous nuclear ribonucleoprotein H isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    8. NM_001362528.1 → NP_001349457.1  heterogeneous nuclear ribonucleoprotein H isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    9. NM_001362529.1 → NP_001349458.1  heterogeneous nuclear ribonucleoprotein H isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    10. NM_001362530.1 → NP_001349459.1  heterogeneous nuclear ribonucleoprotein H isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    11. NM_001362532.1 → NP_001349461.1  heterogeneous nuclear ribonucleoprotein H isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    12. NM_001362533.1 → NP_001349462.1  heterogeneous nuclear ribonucleoprotein H isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL645904
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    13. NM_001362534.1 → NP_001349463.1  heterogeneous nuclear ribonucleoprotein H isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL645904
      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    14. NM_021510.3 → NP_067485.1  heterogeneous nuclear ribonucleoprotein H isoform 2

      See identical proteins and their annotated locations for NP_067485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL645904, BE952242, BQ178089, BU058854, BY787002, CO428102
      Consensus CDS
      CCDS24634.1
      UniProtKB/Swiss-Prot
      O35737
      UniProtKB/TrEMBL
      Q811L7
      Related
      ENSMUSP00000070503.8, ENSMUST00000069304.14
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50266084..50277355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246205.2 → XP_030102065.1  heterogeneous nuclear ribonucleoprotein H isoform X7

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    2. XM_036156886.1 → XP_036012779.1  heterogeneous nuclear ribonucleoprotein H isoform X13

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    3. XM_036156883.1 → XP_036012776.1  heterogeneous nuclear ribonucleoprotein H isoform X11

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    4. XM_036156884.1 → XP_036012777.1  heterogeneous nuclear ribonucleoprotein H isoform X13

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    5. XM_036156878.1 → XP_036012771.1  heterogeneous nuclear ribonucleoprotein H isoform X4

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    6. XM_036156875.1 → XP_036012768.1  heterogeneous nuclear ribonucleoprotein H isoform X1

      UniProtKB/TrEMBL
      Q8C2Q7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    7. XM_006533879.3 → XP_006533942.1  heterogeneous nuclear ribonucleoprotein H isoform X3

      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_017314694.2 → XP_017170183.1  heterogeneous nuclear ribonucleoprotein H isoform X10

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    9. XM_030246204.2 → XP_030102064.1  heterogeneous nuclear ribonucleoprotein H isoform X6

      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_036156880.1 → XP_036012773.1  heterogeneous nuclear ribonucleoprotein H isoform X7

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    11. XM_036156877.1 → XP_036012770.1  heterogeneous nuclear ribonucleoprotein H isoform X2

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    12. XM_036156885.1 → XP_036012778.1  heterogeneous nuclear ribonucleoprotein H isoform X13

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    13. XM_036156882.1 → XP_036012775.1  heterogeneous nuclear ribonucleoprotein H isoform X11

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    14. XM_036156881.1 → XP_036012774.1  heterogeneous nuclear ribonucleoprotein H isoform X9

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    15. XM_006533881.4 → XP_006533944.1  heterogeneous nuclear ribonucleoprotein H isoform X8

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    16. XM_036156876.1 → XP_036012769.1  heterogeneous nuclear ribonucleoprotein H isoform X1

      UniProtKB/TrEMBL
      Q8C2Q7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    17. XM_036156879.1 → XP_036012772.1  heterogeneous nuclear ribonucleoprotein H isoform X5

      UniProtKB/Swiss-Prot
      O35737
      UniProtKB/TrEMBL
      Q811L7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    18. XM_030246212.2 → XP_030102072.1  heterogeneous nuclear ribonucleoprotein H isoform X13

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    19. XM_030246209.2 → XP_030102069.1  heterogeneous nuclear ribonucleoprotein H isoform X11

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    20. XM_030246207.1 → XP_030102067.1  heterogeneous nuclear ribonucleoprotein H isoform X9

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    21. XM_030246206.1 → XP_030102066.1  heterogeneous nuclear ribonucleoprotein H isoform X8

      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    22. XM_006533877.4 → XP_006533940.1  heterogeneous nuclear ribonucleoprotein H isoform X1

      See identical proteins and their annotated locations for XP_006533940.1

      UniProtKB/TrEMBL
      Q8C2Q7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    23. XM_030246210.2 → XP_030102070.1  heterogeneous nuclear ribonucleoprotein H isoform X12

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      cd12734
      Location:81 → 156
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:54 → 82
      zf-RNPHF; RNPHF zinc finger

    24. XM_017314697.3 → XP_017170186.1  heterogeneous nuclear ribonucleoprotein H isoform X14

      UniProtKB/TrEMBL
      Q3TNG9
      Conserved Domains (2) summary
      cd12734
      Location:81 → 156
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:54 → 82
      zf-RNPHF; RNPHF zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35737.3 GenPept UniProtKB/Swiss-Prot:O35737

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