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    Star steroidogenic acute regulatory protein [ Mus musculus (house mouse) ]

    Gene ID: 20845, updated on 9-Dec-2024

    Summary

    Official Symbol
    Starprovided by MGI
    Official Full Name
    steroidogenic acute regulatory proteinprovided by MGI
    Primary source
    MGI:MGI:102760
    See related
    Ensembl:ENSMUSG00000031574 AllianceGenome:MGI:102760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    stARD1; D8Ertd419e
    Summary
    Enables cholesterol binding activity. Acts upstream of or within cellular lipid metabolic process; glucocorticoid metabolic process; and regulation of steroid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; extraembryonic component; reproductive system; and urogenital ridge. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward adrenal adult (RPKM 849.8) See more
    Orthologs
    NEW
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    Genomic context

    See Star in Genome Data Viewer
    Location:
    8 A2; 8 14.17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26298502..26306010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25808474..25815982)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 4 Neighboring gene electron transferring flavoprotein, alpha polypeptide pseudogene Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene Star 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_20984 Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E9309 Neighboring gene potassium channel, subfamily U, member 1 Neighboring gene STARR-seq mESC enhancer starr_20986 Neighboring gene STARR-seq mESC enhancer starr_20989

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biphenyl metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epinephrine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to follicle-stimulating hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-alpha IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to luteinizing hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dibenzo-p-dioxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diterpenoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucocorticoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insecticide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phenol-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phthalate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to benzoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fungicide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to herbicide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to leptin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in testosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial crista IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    steroidogenic acute regulatory protein, mitochondrial
    Names
    START domain-containing protein 1
    luteinizing hormone-induced protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011485.5NP_035615.2  steroidogenic acute regulatory protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_035615.2

      Status: VALIDATED

      Source sequence(s)
      AK019725, AK054470, AK136327
      Consensus CDS
      CCDS22203.1
      UniProtKB/Swiss-Prot
      P51557, Q543A5, Q924Y5, Q9D2G1
      Related
      ENSMUSP00000033979.5, ENSMUST00000033979.6
      Conserved Domains (1) summary
      cd08905
      Location:69277
      START_STARD1-like; Cholesterol-binding START domain of mammalian STARD1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26298502..26306010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)