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    Zfp219 zinc finger protein 219 [ Mus musculus (house mouse) ]

    Gene ID: 69890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp219provided by MGI
    Official Full Name
    zinc finger protein 219provided by MGI
    Primary source
    MGI:MGI:1917140
    See related
    Ensembl:ENSMUSG00000049295 AllianceGenome:MGI:1917140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf219; 2010302A17Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in limb bud formation; positive regulation of chondrocyte differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ZNF219 (zinc finger protein 219). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 27.5), CNS E11.5 (RPKM 23.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp219 in Genome Data Viewer
    Location:
    14 C2; 14 26.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52243532..52258597, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52006075..52021140, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 6a (zeta) pseudogene Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene predicted gene, 16617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628339-52628522 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628697-52628806 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52639962-52640145 Neighboring gene STARR-seq mESC enhancer starr_36687 Neighboring gene transmembrane protein 253 Neighboring gene olfactory receptor family 5 subfamily AU member 1 Neighboring gene STARR-seq mESC enhancer starr_36689 Neighboring gene STARR-seq mESC enhancer starr_36690 Neighboring gene STARR-seq mESC enhancer starr_36694 Neighboring gene predicted gene, 22354

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity. El Abdellaoui-Soussi F, et al. Int J Mol Sci, 2022 Aug 24. PMID 36076959, Free PMC Article
    2. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Hildebrand JD, et al. Mol Cell Biol, 2002 Aug. PMID 12101226, Free PMC Article
    3. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. Takigawa Y, et al. J Cell Sci, 2010 Nov 1. PMID 20940257
    4. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Paces-Fessy M, et al. Biochem J, 2004 Mar 1. PMID 14611647, Free PMC Article
    5. A protein interaction network for pluripotency of embryonic stem cells. Wang J, et al. Nature, 2006 Nov 16. PMID 17093407

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
      Title: Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in limb bud formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 219

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253694.1 → NP_001240623.1  zinc finger protein 219 isoform 1

      See identical proteins and their annotated locations for NP_001240623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same isoform 1.
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS36916.1
      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Related
      ENSMUSP00000126854.3, ENSMUST00000166169.4
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. NM_001253695.1 → NP_001240624.1  zinc finger protein 219 isoform 1

      See identical proteins and their annotated locations for NP_001240624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same isoform 1.
      Source sequence(s)
      AA881069, AK008516, AK053445, CJ184433
      Consensus CDS
      CCDS36916.1
      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Related
      ENSMUSP00000154709.2, ENSMUST00000226522.2
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. NM_001253696.1 → NP_001240625.1  zinc finger protein 219 isoform 2

      See identical proteins and their annotated locations for NP_001240625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88657.1
      UniProtKB/TrEMBL
      Q4VA98
      Related
      ENSMUSP00000153966.2, ENSMUST00000228580.2
      Conserved Domains (4) summary
      sd00017
      Location:458 → 478
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:458 → 478
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:470 → 492
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:484 → 507
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. NM_027248.2 → NP_081524.2  zinc finger protein 219 isoform 1

      See identical proteins and their annotated locations for NP_081524.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 encode the same isoform 1.
      Source sequence(s)
      AB063578, AK008516, AK053445, BQ890732
      Consensus CDS
      CCDS36916.1
      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Related
      ENSMUSP00000068184.8, ENSMUST00000067549.15
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52243532..52258597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316180.1 → XP_017171669.1  zinc finger protein 219 isoform X1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_006519504.5 → XP_006519567.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519567.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_006519499.5 → XP_006519562.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519562.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_036158843.1 → XP_036014736.1  zinc finger protein 219 isoform X1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_006519503.3 → XP_006519566.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519566.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_036158844.1 → XP_036014737.1  zinc finger protein 219 isoform X1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    7. XM_036158842.1 → XP_036014735.1  zinc finger protein 219 isoform X1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    8. XM_006519506.5 → XP_006519569.1  zinc finger protein 219 isoform X2

      See identical proteins and their annotated locations for XP_006519569.1

      UniProtKB/TrEMBL
      Q4VA98
      Conserved Domains (4) summary
      sd00017
      Location:458 → 478
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:458 → 478
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:470 → 492
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:484 → 507
      zf-H2C2_5; C2H2-type zinc-finger domain

    9. XM_006519505.2 → XP_006519568.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519568.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    10. XM_011245177.2 → XP_011243479.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_011243479.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    11. XM_006519502.4 → XP_006519565.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519565.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    12. XM_006519501.5 → XP_006519564.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519564.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    13. XM_006519498.5 → XP_006519561.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_006519561.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain

    14. XM_011245176.4 → XP_011243478.1  zinc finger protein 219 isoform X1

      See identical proteins and their annotated locations for XP_011243478.1

      UniProtKB/Swiss-Prot
      Q6IQX8, Q921W9, Q924S6, Q9CVF3
      Conserved Domains (4) summary
      sd00017
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:503 → 523
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:515 → 537
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:529 → 552
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQX8.1 GenPept UniProtKB/Swiss-Prot:Q6IQX8

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