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    Spata3 spermatogenesis associated 3 [ Mus musculus (house mouse) ]

    Gene ID: 70060, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spata3provided by MGI
    Official Full Name
    spermatogenesis associated 3provided by MGI
    Primary source
    MGI:MGI:1917310
    See related
    Ensembl:ENSMUSG00000026226 AllianceGenome:MGI:1917310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsarg1; Mtsarg1; 1700011N12Rik; 1700029H01Rik; 4930424D10Rik
    Summary
    Orthologous to human SPATA3 (spermatogenesis associated 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 155.9) See more
    Orthologs
    human all
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    Genomic context

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    See Spata3 in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85945728..85957683)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86018031..86029961)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5777 Neighboring gene predicted gene, 53569 Neighboring gene zinc finger protein 617 pseudogene Neighboring gene RIKEN cDNA 2810459M11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1552 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Neighboring gene predicted gene, 22786

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice. Girault MS, et al. Int J Mol Sci, 2021 Feb 16. PMID 33669425, Free PMC Article
    2. Molecular cloning and characterization of a novel transcript variant of Mtsarg1 gene. Li L, et al. Mol Biol Rep, 2009 May. PMID 18551385
    3. [Molecular cloning for testis spermatogenesis cell apoptosis related gene TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene]. Fu JJ, et al. Yi Chuan Xue Bao, 2003 Jan. PMID 12812072
    4. Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3. Wang Y, et al. Parasitol Res, 2016 Jul. PMID 27053129
    5. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice.
      Title: Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice.
    2. Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development.
      Title: Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.
    3. Mtsarg1 and Mtsarg1-beta may play an important role in mouse testicular function and in spermatocyte development.
      Title: Molecular cloning and characterization of a novel transcript variant of Mtsarg1 gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 3
    Names
    testis and spermatogenesis cell apoptosis related gene 1
    testis and spermatogenesis cell apoptosis related protein 1
    testis and spermatogenesis cell-related protein 1
    testis spermatocyte apoptosis-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122732.2 → NP_001116204.1  spermatogenesis-associated protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001116204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the CDS, compared to variant 2. The resulting isoform (3) lacks one amino acid when it is compared to isoform 2. Variants 3 and 4 both encode the same isoform (3).
      Source sequence(s)
      AC102506
      Consensus CDS
      CCDS15116.1
      UniProtKB/TrEMBL
      F6UTK3, Q3V2M5
      Related
      ENSMUSP00000116903.2, ENSMUST00000130504.8
      Conserved Domains (1) summary
      pfam15662
      Location:9 → 191
      SPATA3; Spermatogenesis-associated protein 3 family

    2. NM_001379365.1 → NP_001366294.1  spermatogenesis-associated protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 2, encodes the longest isoform (2).
      Source sequence(s)
      AC102506
      UniProtKB/Swiss-Prot
      Q80ZS4, Q9D5L5, Q9D9T6, Q9DAF5
      UniProtKB/TrEMBL
      F6UTK3
      Related
      ENSMUSP00000124671.2, ENSMUST00000159876.8
      Conserved Domains (1) summary
      pfam15662
      Location:9 → 192
      SPATA3; Spermatogenesis-associated protein 3 family

    3. NM_027029.3 → NP_081305.1  spermatogenesis-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_081305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses two different splice sites in the CDS and a different segment for its 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC102506
      Consensus CDS
      CCDS48301.1
      UniProtKB/TrEMBL
      Q6P8X3
      Related
      ENSMUSP00000123194.2, ENSMUST00000152501.8
      Conserved Domains (1) summary
      pfam15662
      Location:9 → 158
      SPATA3; Spermatogenesis-associated protein 3 family

    4. NM_027300.4 → NP_081576.2  spermatogenesis-associated protein 3 isoform 2

      See identical proteins and their annotated locations for NP_081576.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Variants 2 and 5 both encode the same isoform (2).
      Source sequence(s)
      AC102506
      Consensus CDS
      CCDS35643.1
      UniProtKB/Swiss-Prot
      Q80ZS4, Q9D5L5, Q9D9T6, Q9DAF5
      UniProtKB/TrEMBL
      F6UTK3
      Related
      ENSMUSP00000050509.7, ENSMUST00000052854.13
      Conserved Domains (1) summary
      pfam15662
      Location:9 → 192
      SPATA3; Spermatogenesis-associated protein 3 family

    5. NM_028647.5 → NP_082923.1  spermatogenesis-associated protein 3 isoform 3

      See identical proteins and their annotated locations for NP_082923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the CDS and a different segment for its 3' UTR, compared to variant 2. The resulting protein isoform (3) lacks one amino acid when it is compared to isoform 2. Variants 3 and 4 both encode the same isoform (3).
      Source sequence(s)
      AC102506
      Consensus CDS
      CCDS15116.1
      UniProtKB/TrEMBL
      F6UTK3, Q3V2M5
      Related
      ENSMUSP00000108971.2, ENSMUST00000113344.8
      Conserved Domains (1) summary
      pfam15662
      Location:9 → 191
      SPATA3; Spermatogenesis-associated protein 3 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85945728..85957683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242863.2 → XP_030098723.2  spermatogenesis-associated protein 3 isoform X4

      Conserved Domains (1) summary
      pfam15443
      Location:192 → 253
      DUF4630; Domain of unknown function (DUF4630)

    2. XM_011248072.4 → XP_011246374.3  spermatogenesis-associated protein 3 isoform X5

    3. XM_030242861.2 → XP_030098721.2  spermatogenesis-associated protein 3 isoform X3

    4. XM_036153549.1 → XP_036009442.1  spermatogenesis-associated protein 3 isoform X3

    5. XM_030242857.2 → XP_030098717.1  spermatogenesis-associated protein 3 isoform X1

      Conserved Domains (1) summary
      pfam15662
      Location:110 → 293
      SPATA3; Spermatogenesis-associated protein 3 family

    6. XM_030242858.2 → XP_030098718.1  spermatogenesis-associated protein 3 isoform X2

      Conserved Domains (1) summary
      pfam15662
      Location:110 → 292
      SPATA3; Spermatogenesis-associated protein 3 family

    7. XM_011248071.4 → XP_011246373.1  spermatogenesis-associated protein 3 isoform X1

      Conserved Domains (1) summary
      pfam15662
      Location:110 → 293
      SPATA3; Spermatogenesis-associated protein 3 family

    8. XM_030242859.2 → XP_030098719.1  spermatogenesis-associated protein 3 isoform X2

      Conserved Domains (1) summary
      pfam15662
      Location:110 → 292
      SPATA3; Spermatogenesis-associated protein 3 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9T6.2 GenPept UniProtKB/Swiss-Prot:Q9D9T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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