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    Caskin1 CASK interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 268932, updated on 9-Dec-2024

    Summary

    Official Symbol
    Caskin1provided by MGI
    Official Full Name
    CASK interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2442952
    See related
    Ensembl:ENSMUSG00000033597 AllianceGenome:MGI:2442952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1306; C130061I24; 3300002N10Rik; C630036E02Rik
    Summary
    Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in regulation of postsynaptic density assembly. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adrenal gland; bladder; eye; intestine; and nervous system. Orthologous to human CASKIN1 (CASK interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 20.2), CNS E18 (RPKM 20.0) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Caskin1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.4 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24706871..24727883)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24487897..24508909)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphoglycolate phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E5578 Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_42087 Neighboring gene TNF receptor-associated factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E33 Neighboring gene RAB26, member RAS oncogene family, opposite strand Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene RAB26, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of postsynaptic density assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic density assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360469.1NP_001347398.1  caskin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132367, AC154237
      Consensus CDS
      CCDS89007.1
      UniProtKB/TrEMBL
      B7ZNJ3
      Related
      ENSMUSP00000157196.2, ENSMUST00000234717.2
      Conserved Domains (9) summary
      cd09498
      Location:478540
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12062
      Location:284345
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      cd00204
      Location:43168
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:114145
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:769
      Ank_4; Ankyrin repeats (many copies)
      pfam16600
      Location:373421
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:12981360
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:807878
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      cl25751
      Location:616758
      DUF4045; Domain of unknown function (DUF4045)
    2. NM_027937.2NP_082213.2  caskin-1 isoform 1

      See identical proteins and their annotated locations for NP_082213.2

      Status: VALIDATED

      Source sequence(s)
      BC059916, BC060720, CJ127019
      Consensus CDS
      CCDS50013.1
      UniProtKB/Swiss-Prot
      Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0
      UniProtKB/TrEMBL
      B7ZNJ3
      Related
      ENSMUSP00000024958.8, ENSMUST00000024958.9
      Conserved Domains (12) summary
      cd09497
      Location:475540
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:541611
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:474536
      SAM; Sterile alpha motif
      cd12062
      Location:284345
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      cd00204
      Location:43168
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:119218
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:769
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:208261
      Ank_5; Ankyrin repeats (many copies)
      pfam16600
      Location:373421
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:13691431
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:878949
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:114145
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24706871..24727883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524313.3XP_006524376.1  caskin-1 isoform X1

      UniProtKB/TrEMBL
      B7ZNJ3
      Conserved Domains (11) summary
      PTZ00449
      Location:694836
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09497
      Location:482547
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:548618
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12062
      Location:291352
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      COG0666
      Location:55258
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:121152
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:126225
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:380428
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:13761438
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:885956
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      cl39094
      Location:232289
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_030249826.1XP_030105686.1  caskin-1 isoform X4

      UniProtKB/TrEMBL
      B7ZNJ3
      Conserved Domains (10) summary
      PTZ00449
      Location:623765
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09498
      Location:485547
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12062
      Location:291352
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      COG0666
      Location:55258
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:121152
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:126225
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:380428
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:13051367
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:814885
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      cl39094
      Location:232289
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_036160626.1XP_036016519.1  caskin-1 isoform X2

      UniProtKB/TrEMBL
      B7ZNJ3
      Conserved Domains (11) summary
      PTZ00449
      Location:667809
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09497
      Location:455520
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:521591
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12062
      Location:264325
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      COG0666
      Location:28231
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:94125
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:99198
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:353401
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:13491411
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:858929
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      cl39094
      Location:205265
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_036160627.1XP_036016520.1  caskin-1 isoform X3

      UniProtKB/TrEMBL
      B7ZNJ3
      Conserved Domains (10) summary
      PTZ00449
      Location:660802
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09497
      Location:448513
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:514584
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12062
      Location:257318
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      PHA03095
      Location:14231
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:92191
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:346394
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:13421404
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:851922
      Caskin-Pro-rich; Proline rich region of Caskin proteins
    5. XM_006524316.5XP_006524379.1  caskin-1 isoform X5

      Conserved Domains (5) summary
      PTZ00449
      Location:252394
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09497
      Location:42105
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:106176
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      pfam16632
      Location:934996
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:443514
      Caskin-Pro-rich; Proline rich region of Caskin proteins